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Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area

Growing evidence points to vasopressin (AVP) as a social behavior regulator modulating various memory processes and involved in pathologies such as mood disorders, anxiety and depression. Accordingly, AVP antagonists are actually envisaged as putative treatments. However, the underlying mechanisms a...

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Autores principales: Chafai, Magda, Corbani, Maithé, Guillon, Gilles, Desarménien, Michel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517623/
https://www.ncbi.nlm.nih.gov/pubmed/23236353
http://dx.doi.org/10.1371/journal.pone.0049708
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author Chafai, Magda
Corbani, Maithé
Guillon, Gilles
Desarménien, Michel G.
author_facet Chafai, Magda
Corbani, Maithé
Guillon, Gilles
Desarménien, Michel G.
author_sort Chafai, Magda
collection PubMed
description Growing evidence points to vasopressin (AVP) as a social behavior regulator modulating various memory processes and involved in pathologies such as mood disorders, anxiety and depression. Accordingly, AVP antagonists are actually envisaged as putative treatments. However, the underlying mechanisms are poorly characterized, in particular the influence of AVP on cellular or synaptic activities in limbic brain areas involved in social behavior. In the present study, we investigated AVP action on the synapse between the entorhinal cortex and CA2 hippocampal pyramidal neurons, by using both field potential and whole-cell recordings in mice brain acute slices. Short application (1 min) of AVP transiently reduced the synaptic response, only following induction of long-term potentiation (LTP) by high frequency stimulation (HFS) of afferent fibers. The basal synaptic response, measured in the absence of HFS, was not affected. The Schaffer collateral-CA1 synapse was not affected by AVP, even after LTP, while the Schaffer collateral-CA2 synapse was inhibited. Although investigated only recently, this CA2 hippocampal area appears to have a distinctive circuitry and a peculiar role in controlling episodic memory. Accordingly, AVP action on LTP-increased synaptic responses in this limbic structure may contribute to the role of this neuropeptide in controlling memory and social behavior.
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spelling pubmed-35176232012-12-12 Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area Chafai, Magda Corbani, Maithé Guillon, Gilles Desarménien, Michel G. PLoS One Research Article Growing evidence points to vasopressin (AVP) as a social behavior regulator modulating various memory processes and involved in pathologies such as mood disorders, anxiety and depression. Accordingly, AVP antagonists are actually envisaged as putative treatments. However, the underlying mechanisms are poorly characterized, in particular the influence of AVP on cellular or synaptic activities in limbic brain areas involved in social behavior. In the present study, we investigated AVP action on the synapse between the entorhinal cortex and CA2 hippocampal pyramidal neurons, by using both field potential and whole-cell recordings in mice brain acute slices. Short application (1 min) of AVP transiently reduced the synaptic response, only following induction of long-term potentiation (LTP) by high frequency stimulation (HFS) of afferent fibers. The basal synaptic response, measured in the absence of HFS, was not affected. The Schaffer collateral-CA1 synapse was not affected by AVP, even after LTP, while the Schaffer collateral-CA2 synapse was inhibited. Although investigated only recently, this CA2 hippocampal area appears to have a distinctive circuitry and a peculiar role in controlling episodic memory. Accordingly, AVP action on LTP-increased synaptic responses in this limbic structure may contribute to the role of this neuropeptide in controlling memory and social behavior. Public Library of Science 2012-12-07 /pmc/articles/PMC3517623/ /pubmed/23236353 http://dx.doi.org/10.1371/journal.pone.0049708 Text en © 2012 Chafai et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chafai, Magda
Corbani, Maithé
Guillon, Gilles
Desarménien, Michel G.
Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
title Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
title_full Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
title_fullStr Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
title_full_unstemmed Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
title_short Vasopressin Inhibits LTP in the CA2 Mouse Hippocampal Area
title_sort vasopressin inhibits ltp in the ca2 mouse hippocampal area
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517623/
https://www.ncbi.nlm.nih.gov/pubmed/23236353
http://dx.doi.org/10.1371/journal.pone.0049708
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