Cargando…
Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
MtrA is a member of the AraC family of transcriptional regulators and has been shown to play an important role in enhancing transcription of the mtrCDE operon, which encodes a tripartite multidrug efflux pump, when gonococci are exposed to a sublethal level of antimicrobials. Heretofore, the DNA-bin...
Autores principales: | Zalucki, Yaramah M., Dhulipala, Vijaya, Shafer, William M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517864/ https://www.ncbi.nlm.nih.gov/pubmed/23221802 http://dx.doi.org/10.1128/mBio.00446-12 |
Ejemplares similares
-
Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon
por: Rouquette-Loughlin, Corinne E., et al.
Publicado: (2017) -
The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of “off Target” Gene (glnE) Expression
por: Johnson, Paul J. T., et al.
Publicado: (2015) -
Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae
por: Beggs, Grace A., et al.
Publicado: (2019) -
1440. The Genetic Basis for a Neisseria gonorrhoeae Clinical Isolate That Contains mtrR(-79) Mutation But Is Highly Susceptible to Antibiotics Effluxed by the Mtr Pump System
por: Huang, Jianzhong, et al.
Publicado: (2020) -
Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
por: Bolla, Jani Reddy, et al.
Publicado: (2014)