Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging

Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammal...

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Detalles Bibliográficos
Autores principales: Noren Hooten, Nicole, Fitzpatrick, Megan, Kompaniez, Kari, Jacob, Kimberly D., Moore, Brittany R., Nagle, Julia, Barnes, Janice, Lohani, Althaf, Evans, Michele K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517938/
https://www.ncbi.nlm.nih.gov/pubmed/23104860

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