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PERTURBATION OF SODIUM CHANNEL STRUCTURE BY AN INHERITED LONG QT SYNDROME MUTATION

The cardiac voltage-gated sodium channel (Na(V)1.5) underlies impulse conduction in the heart and its depolarization-induced inactivation is essential in control of the duration of the QT interval of the electrocardiogram (ECG). Perturbation of Nav1.5 inactivation by drugs or inherited mutation can...

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Detalles Bibliográficos
Autores principales:	Glaaser, Ian W., Osteen, Jeremiah D., Puckerin, Akil, Sampson, Kevin J., Jin, Xiangshu, Kass, Robert S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518026/ https://www.ncbi.nlm.nih.gov/pubmed/22426227 http://dx.doi.org/10.1038/ncomms1717

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