Cargando…
The Effects of SIRT1 on Alzheimer's Disease Models
Sirtuins are highly conserved NAD(+)-dependent enzymes that were shown to have beneficial effects against age-related diseases. Aging is the major risk factor for all neurodegenerative disorders including Alzheimer's Disease (AD). Sirtuins have been widely studied in the context of AD using dif...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518073/ https://www.ncbi.nlm.nih.gov/pubmed/23251824 http://dx.doi.org/10.1155/2012/509529 |
_version_ | 1782252514222014464 |
---|---|
author | Donmez, Gizem |
author_facet | Donmez, Gizem |
author_sort | Donmez, Gizem |
collection | PubMed |
description | Sirtuins are highly conserved NAD(+)-dependent enzymes that were shown to have beneficial effects against age-related diseases. Aging is the major risk factor for all neurodegenerative disorders including Alzheimer's Disease (AD). Sirtuins have been widely studied in the context of AD using different mouse models. In most of these studies, overexpression of SIRT1 has been shown to have protective effects against AD. Therefore, designing therapeutics based on increasing SIRT1 activity might be important for investigating the ways of treatment for this disease. This paper summarizes the recent research on the effect of SIRT1 in AD animal models and also the potential of SIRT1 being a therapeutical target for AD. |
format | Online Article Text |
id | pubmed-3518073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35180732012-12-18 The Effects of SIRT1 on Alzheimer's Disease Models Donmez, Gizem Int J Alzheimers Dis Review Article Sirtuins are highly conserved NAD(+)-dependent enzymes that were shown to have beneficial effects against age-related diseases. Aging is the major risk factor for all neurodegenerative disorders including Alzheimer's Disease (AD). Sirtuins have been widely studied in the context of AD using different mouse models. In most of these studies, overexpression of SIRT1 has been shown to have protective effects against AD. Therefore, designing therapeutics based on increasing SIRT1 activity might be important for investigating the ways of treatment for this disease. This paper summarizes the recent research on the effect of SIRT1 in AD animal models and also the potential of SIRT1 being a therapeutical target for AD. Hindawi Publishing Corporation 2012 2012-12-03 /pmc/articles/PMC3518073/ /pubmed/23251824 http://dx.doi.org/10.1155/2012/509529 Text en Copyright © 2012 Gizem Donmez. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Donmez, Gizem The Effects of SIRT1 on Alzheimer's Disease Models |
title | The Effects of SIRT1 on Alzheimer's Disease Models |
title_full | The Effects of SIRT1 on Alzheimer's Disease Models |
title_fullStr | The Effects of SIRT1 on Alzheimer's Disease Models |
title_full_unstemmed | The Effects of SIRT1 on Alzheimer's Disease Models |
title_short | The Effects of SIRT1 on Alzheimer's Disease Models |
title_sort | effects of sirt1 on alzheimer's disease models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518073/ https://www.ncbi.nlm.nih.gov/pubmed/23251824 http://dx.doi.org/10.1155/2012/509529 |
work_keys_str_mv | AT donmezgizem theeffectsofsirt1onalzheimersdiseasemodels AT donmezgizem effectsofsirt1onalzheimersdiseasemodels |