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Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides
PURPOSE: Triplex-forming oligonucleotides (TFO) bind to the DNA double helix in a sequence-specific manner. Therefore, TFO seem to be a suitable carrier for Auger electron emitters to damage exclusively targeted DNA sequences, e.g., in tumor cells. We studied the influence of I-125 labeled TFO with...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Informa Healthcare
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518296/ https://www.ncbi.nlm.nih.gov/pubmed/22694342 http://dx.doi.org/10.3109/09553002.2012.702298 |