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Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides

PURPOSE: Triplex-forming oligonucleotides (TFO) bind to the DNA double helix in a sequence-specific manner. Therefore, TFO seem to be a suitable carrier for Auger electron emitters to damage exclusively targeted DNA sequences, e.g., in tumor cells. We studied the influence of I-125 labeled TFO with...

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Detalles Bibliográficos
Autores principales:	Dahmen, Volker, Kriehuber, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Informa Healthcare 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518296/ https://www.ncbi.nlm.nih.gov/pubmed/22694342 http://dx.doi.org/10.3109/09553002.2012.702298

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