Reversible switching between epigenetic states in honeybee behavioral subcastes

In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker/queen castes, but substantial differences between nurses...

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Detalles Bibliográficos
Autores principales: Herb, Brian R., Wolschin, Florian, Hansen, Kasper D., Aryee, Martin J., Langmead, Ben, Irizarry, Rafael, Amdam, Gro V., Feinberg, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518384/
https://www.ncbi.nlm.nih.gov/pubmed/22983211
http://dx.doi.org/10.1038/nn.3218
Descripción
Sumario:In honeybee societies, distinct caste phenotypes are created from the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phenotypes. We found no differences in DNA methylation between irreversible worker/queen castes, but substantial differences between nurses and forager subcastes. Reverting foragers back to nurses reestablished methylation levels for a majority of genes and provided the first evidence in any organism of reversible epigenetic changes associated with behavior.

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