Atomistic Mechanism for the Activation and Desensitization of an AMPA-Subtype Glutamate Receptor

Ionotropic glutamate receptors (iGluRs) mediate fast excitatory synaptic transmission in the central nervous system. Upon agonist binding, an iGluR opens to allow the flow of cations and subsequently enters into a desensitized state. It remains unclear how agonist binding to the ligand-binding domai...

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Detalles Bibliográficos
Autores principales: Dong, Hao, Zhou, Huan-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518439/
https://www.ncbi.nlm.nih.gov/pubmed/21673675
http://dx.doi.org/10.1038/ncomms1362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518439/
https://www.ncbi.nlm.nih.gov/pubmed/21673675
http://dx.doi.org/10.1038/ncomms1362

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