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The IRF family of transcription factors: Inception, impact and implications in oncogenesis

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical...

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Detalles Bibliográficos
Autores principales: Yanai, Hideyuki, Negishi, Hideo, Taniguchi, Tadatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518510/
https://www.ncbi.nlm.nih.gov/pubmed/23243601
http://dx.doi.org/10.4161/onci.22475
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author Yanai, Hideyuki
Negishi, Hideo
Taniguchi, Tadatsugu
author_facet Yanai, Hideyuki
Negishi, Hideo
Taniguchi, Tadatsugu
author_sort Yanai, Hideyuki
collection PubMed
description Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and—as a consequence—for adaptive immunity. In addition, IRFs have attracted great attentions as they modulate cellular responses that are involved in tumorigenesis. The regulation of oncogenesis by IRFs has important implications for understanding the host susceptibility to several Types of cancers, their progression, as well as the potential for therapeutic interventions.
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spelling pubmed-35185102012-12-14 The IRF family of transcription factors: Inception, impact and implications in oncogenesis Yanai, Hideyuki Negishi, Hideo Taniguchi, Tadatsugu Oncoimmunology Review Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and—as a consequence—for adaptive immunity. In addition, IRFs have attracted great attentions as they modulate cellular responses that are involved in tumorigenesis. The regulation of oncogenesis by IRFs has important implications for understanding the host susceptibility to several Types of cancers, their progression, as well as the potential for therapeutic interventions. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518510/ /pubmed/23243601 http://dx.doi.org/10.4161/onci.22475 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Yanai, Hideyuki
Negishi, Hideo
Taniguchi, Tadatsugu
The IRF family of transcription factors: Inception, impact and implications in oncogenesis
title The IRF family of transcription factors: Inception, impact and implications in oncogenesis
title_full The IRF family of transcription factors: Inception, impact and implications in oncogenesis
title_fullStr The IRF family of transcription factors: Inception, impact and implications in oncogenesis
title_full_unstemmed The IRF family of transcription factors: Inception, impact and implications in oncogenesis
title_short The IRF family of transcription factors: Inception, impact and implications in oncogenesis
title_sort irf family of transcription factors: inception, impact and implications in oncogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518510/
https://www.ncbi.nlm.nih.gov/pubmed/23243601
http://dx.doi.org/10.4161/onci.22475
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