Intratumoral TNFα improves immunotherapy

Solid tumors are frequently resistant to immunotherapy. We demonstrated that low-dose tumor necrosis factorα (TNFα), when directly targeted to the tumor environment, exerts dual effects by improving vessel functionality and activating immune cells. This vascular remodeling in an inflammatory context...

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Detalles Bibliográficos
Autores principales: Johansson, Anna, Hamzah, Juliana, Ganss, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518514/
https://www.ncbi.nlm.nih.gov/pubmed/23243605
http://dx.doi.org/10.4161/onci.20981
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author Johansson, Anna
Hamzah, Juliana
Ganss, Ruth
author_facet Johansson, Anna
Hamzah, Juliana
Ganss, Ruth
author_sort Johansson, Anna
collection PubMed
description Solid tumors are frequently resistant to immunotherapy. We demonstrated that low-dose tumor necrosis factorα (TNFα), when directly targeted to the tumor environment, exerts dual effects by improving vessel functionality and activating immune cells. This vascular remodeling in an inflammatory context enhances active immunotherapy and promotes tumor regression.
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spelling pubmed-35185142012-12-14 Intratumoral TNFα improves immunotherapy Johansson, Anna Hamzah, Juliana Ganss, Ruth Oncoimmunology Author's View Solid tumors are frequently resistant to immunotherapy. We demonstrated that low-dose tumor necrosis factorα (TNFα), when directly targeted to the tumor environment, exerts dual effects by improving vessel functionality and activating immune cells. This vascular remodeling in an inflammatory context enhances active immunotherapy and promotes tumor regression. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518514/ /pubmed/23243605 http://dx.doi.org/10.4161/onci.20981 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Johansson, Anna
Hamzah, Juliana
Ganss, Ruth
Intratumoral TNFα improves immunotherapy
title Intratumoral TNFα improves immunotherapy
title_full Intratumoral TNFα improves immunotherapy
title_fullStr Intratumoral TNFα improves immunotherapy
title_full_unstemmed Intratumoral TNFα improves immunotherapy
title_short Intratumoral TNFα improves immunotherapy
title_sort intratumoral tnfα improves immunotherapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518514/
https://www.ncbi.nlm.nih.gov/pubmed/23243605
http://dx.doi.org/10.4161/onci.20981
work_keys_str_mv AT johanssonanna intratumoraltnfaimprovesimmunotherapy
AT hamzahjuliana intratumoraltnfaimprovesimmunotherapy
AT ganssruth intratumoraltnfaimprovesimmunotherapy

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