Targeting cancer stem cells via dendritic-cell vaccination

Using syngeneic murine tumor models established in immunocompetent hosts, we showed that cancer stem cells are immunogenic and can be selectively targeted by dendritic cell-based vaccines. This new approach induced both humoral and cellular immune responses and conferred significantly superior antit...

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Detalles Bibliográficos
Autores principales: Teitz-Tennenbaum, Seagal, Wicha, Max S., Chang, Alfred E., Li, Qiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518516/
https://www.ncbi.nlm.nih.gov/pubmed/23243607
http://dx.doi.org/10.4161/onci.21026
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author Teitz-Tennenbaum, Seagal
Wicha, Max S.
Chang, Alfred E.
Li, Qiao
author_facet Teitz-Tennenbaum, Seagal
Wicha, Max S.
Chang, Alfred E.
Li, Qiao
author_sort Teitz-Tennenbaum, Seagal
collection PubMed
description Using syngeneic murine tumor models established in immunocompetent hosts, we showed that cancer stem cells are immunogenic and can be selectively targeted by dendritic cell-based vaccines. This new approach induced both humoral and cellular immune responses and conferred significantly superior antitumor immunity as compared with conventional vaccines.
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spelling pubmed-35185162012-12-14 Targeting cancer stem cells via dendritic-cell vaccination Teitz-Tennenbaum, Seagal Wicha, Max S. Chang, Alfred E. Li, Qiao Oncoimmunology Author's View Using syngeneic murine tumor models established in immunocompetent hosts, we showed that cancer stem cells are immunogenic and can be selectively targeted by dendritic cell-based vaccines. This new approach induced both humoral and cellular immune responses and conferred significantly superior antitumor immunity as compared with conventional vaccines. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518516/ /pubmed/23243607 http://dx.doi.org/10.4161/onci.21026 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Teitz-Tennenbaum, Seagal
Wicha, Max S.
Chang, Alfred E.
Li, Qiao
Targeting cancer stem cells via dendritic-cell vaccination
title Targeting cancer stem cells via dendritic-cell vaccination
title_full Targeting cancer stem cells via dendritic-cell vaccination
title_fullStr Targeting cancer stem cells via dendritic-cell vaccination
title_full_unstemmed Targeting cancer stem cells via dendritic-cell vaccination
title_short Targeting cancer stem cells via dendritic-cell vaccination
title_sort targeting cancer stem cells via dendritic-cell vaccination
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518516/
https://www.ncbi.nlm.nih.gov/pubmed/23243607
http://dx.doi.org/10.4161/onci.21026
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