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High-throughput approaches to discover novel immunomodulatory agents for cancer
The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity. We documented that the interaction between cancer cells, their str...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518518/ https://www.ncbi.nlm.nih.gov/pubmed/23243609 http://dx.doi.org/10.4161/onci.21058 |
| _version_ | 1782252567640670208 |
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| author | McMillin, Douglas W. Mitsiades, Constantine S. |
| author_facet | McMillin, Douglas W. Mitsiades, Constantine S. |
| author_sort | McMillin, Douglas W. |
| collection | PubMed |
| description | The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity. We documented that the interaction between cancer cells, their stroma, anticancer agents and cells from the innate system are critical for determining the response of tumors to immunomodulatory strategies. |
| format | Online Article Text |
| id | pubmed-3518518 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35185182012-12-14 High-throughput approaches to discover novel immunomodulatory agents for cancer McMillin, Douglas W. Mitsiades, Constantine S. Oncoimmunology Author's View The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell activity. We documented that the interaction between cancer cells, their stroma, anticancer agents and cells from the innate system are critical for determining the response of tumors to immunomodulatory strategies. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518518/ /pubmed/23243609 http://dx.doi.org/10.4161/onci.21058 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View McMillin, Douglas W. Mitsiades, Constantine S. High-throughput approaches to discover novel immunomodulatory agents for cancer |
| title | High-throughput approaches to discover novel immunomodulatory agents for cancer |
| title_full | High-throughput approaches to discover novel immunomodulatory agents for cancer |
| title_fullStr | High-throughput approaches to discover novel immunomodulatory agents for cancer |
| title_full_unstemmed | High-throughput approaches to discover novel immunomodulatory agents for cancer |
| title_short | High-throughput approaches to discover novel immunomodulatory agents for cancer |
| title_sort | high-throughput approaches to discover novel immunomodulatory agents for cancer |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518518/ https://www.ncbi.nlm.nih.gov/pubmed/23243609 http://dx.doi.org/10.4161/onci.21058 |
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