L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?

We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax(®))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25,...

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Detalles Bibliográficos
Autores principales: DeGregorio, Michael, Wurz, Gregory T., Gutierrez, Audrey, Wolf, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518524/
https://www.ncbi.nlm.nih.gov/pubmed/23243615
http://dx.doi.org/10.4161/onci.21129
Descripción
Sumario:We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax(®))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25, only letrozole increased the survival advantage of L-BLP25.

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