L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?

We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax(®))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25,...

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Detalles Bibliográficos
Autores principales: DeGregorio, Michael, Wurz, Gregory T., Gutierrez, Audrey, Wolf, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518524/
https://www.ncbi.nlm.nih.gov/pubmed/23243615
http://dx.doi.org/10.4161/onci.21129
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author DeGregorio, Michael
Wurz, Gregory T.
Gutierrez, Audrey
Wolf, Michael
author_facet DeGregorio, Michael
Wurz, Gregory T.
Gutierrez, Audrey
Wolf, Michael
author_sort DeGregorio, Michael
collection PubMed
description We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax(®))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25, only letrozole increased the survival advantage of L-BLP25.
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spelling pubmed-35185242012-12-14 L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible? DeGregorio, Michael Wurz, Gregory T. Gutierrez, Audrey Wolf, Michael Oncoimmunology Author's View We have recently reported immunomodulatory effects for tamoxifen and letrozole on the L-BLP25 (Stimuvax(®))-induced immune response in a MUC1-expressing breast cancer mouse model. While neither tamoxifen nor letrozole appeared to interfere with the Th1-polarized cytokine response induced by L-BLP25, only letrozole increased the survival advantage of L-BLP25. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518524/ /pubmed/23243615 http://dx.doi.org/10.4161/onci.21129 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
DeGregorio, Michael
Wurz, Gregory T.
Gutierrez, Audrey
Wolf, Michael
L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
title L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
title_full L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
title_fullStr L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
title_full_unstemmed L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
title_short L-BLP25 vaccine plus letrozole for breast cancer: Is translation possible?
title_sort l-blp25 vaccine plus letrozole for breast cancer: is translation possible?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518524/
https://www.ncbi.nlm.nih.gov/pubmed/23243615
http://dx.doi.org/10.4161/onci.21129
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AT gutierrezaudrey lblp25vaccineplusletrozoleforbreastcanceristranslationpossible
AT wolfmichael lblp25vaccineplusletrozoleforbreastcanceristranslationpossible

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