A new dynamic model of three cell interactions for CTL responses

The exact mechanisms of CD4 help in the generation of memory cytotoxic T lymphocytes (CTLs) remain largely illusive. We propose that dendritic cells (DCs) first interact with CD4(+) T cells, resulting in DC licensing and CD4(+) T-cell priming. Thereafter, CD8(+) T cells can receive stimulatory signa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed, Khawaja Ashfaque, Wang, Lu, Xiang, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518527/
https://www.ncbi.nlm.nih.gov/pubmed/23243618
http://dx.doi.org/10.4161/onci.21175
_version_ 1782252569673859072
author Ahmed, Khawaja Ashfaque
Wang, Lu
Xiang, Jim
author_facet Ahmed, Khawaja Ashfaque
Wang, Lu
Xiang, Jim
author_sort Ahmed, Khawaja Ashfaque
collection PubMed
description The exact mechanisms of CD4 help in the generation of memory cytotoxic T lymphocytes (CTLs) remain largely illusive. We propose that dendritic cells (DCs) first interact with CD4(+) T cells, resulting in DC licensing and CD4(+) T-cell priming. Thereafter, CD8(+) T cells can receive stimulatory signals from DC-CD4(+) T-cell clusters and as well as individually from licensed DCs and primed CD4(+) T cells.
format Online
Article
Text
id pubmed-3518527
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-35185272012-12-14 A new dynamic model of three cell interactions for CTL responses Ahmed, Khawaja Ashfaque Wang, Lu Xiang, Jim Oncoimmunology Author's View The exact mechanisms of CD4 help in the generation of memory cytotoxic T lymphocytes (CTLs) remain largely illusive. We propose that dendritic cells (DCs) first interact with CD4(+) T cells, resulting in DC licensing and CD4(+) T-cell priming. Thereafter, CD8(+) T cells can receive stimulatory signals from DC-CD4(+) T-cell clusters and as well as individually from licensed DCs and primed CD4(+) T cells. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518527/ /pubmed/23243618 http://dx.doi.org/10.4161/onci.21175 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ahmed, Khawaja Ashfaque
Wang, Lu
Xiang, Jim
A new dynamic model of three cell interactions for CTL responses
title A new dynamic model of three cell interactions for CTL responses
title_full A new dynamic model of three cell interactions for CTL responses
title_fullStr A new dynamic model of three cell interactions for CTL responses
title_full_unstemmed A new dynamic model of three cell interactions for CTL responses
title_short A new dynamic model of three cell interactions for CTL responses
title_sort new dynamic model of three cell interactions for ctl responses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518527/
https://www.ncbi.nlm.nih.gov/pubmed/23243618
http://dx.doi.org/10.4161/onci.21175
work_keys_str_mv AT ahmedkhawajaashfaque anewdynamicmodelofthreecellinteractionsforctlresponses
AT wanglu anewdynamicmodelofthreecellinteractionsforctlresponses
AT xiangjim anewdynamicmodelofthreecellinteractionsforctlresponses
AT ahmedkhawajaashfaque newdynamicmodelofthreecellinteractionsforctlresponses
AT wanglu newdynamicmodelofthreecellinteractionsforctlresponses
AT xiangjim newdynamicmodelofthreecellinteractionsforctlresponses

Ejemplares similares