Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell popula...

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Detalles Bibliográficos
Autores principales: Fujimura, Taku, Kambayashi, Yumi, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518528/
https://www.ncbi.nlm.nih.gov/pubmed/23243619
http://dx.doi.org/10.4161/onci.21176
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author Fujimura, Taku
Kambayashi, Yumi
Aiba, Setsuya
author_facet Fujimura, Taku
Kambayashi, Yumi
Aiba, Setsuya
author_sort Fujimura, Taku
collection PubMed
description Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.
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spelling pubmed-35185282012-12-14 Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth Fujimura, Taku Kambayashi, Yumi Aiba, Setsuya Oncoimmunology Author's View Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518528/ /pubmed/23243619 http://dx.doi.org/10.4161/onci.21176 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Fujimura, Taku
Kambayashi, Yumi
Aiba, Setsuya
Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
title Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
title_full Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
title_fullStr Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
title_full_unstemmed Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
title_short Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth
title_sort crosstalk between regulatory t cells (tregs) and myeloid derived suppressor cells (mdscs) during melanoma growth
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518528/
https://www.ncbi.nlm.nih.gov/pubmed/23243619
http://dx.doi.org/10.4161/onci.21176
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