Human Th17 cells in patients with cancer: Friends or foe?

The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions...

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Autores principales: Greten, Tim F., Zhao, Fei, Gamrekelashvili, Jaba, Korangy, Firouzeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518530/
https://www.ncbi.nlm.nih.gov/pubmed/23243621
http://dx.doi.org/10.4161/onci.21245
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author Greten, Tim F.
Zhao, Fei
Gamrekelashvili, Jaba
Korangy, Firouzeh
author_facet Greten, Tim F.
Zhao, Fei
Gamrekelashvili, Jaba
Korangy, Firouzeh
author_sort Greten, Tim F.
collection PubMed
description The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma.
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spelling pubmed-35185302012-12-14 Human Th17 cells in patients with cancer: Friends or foe? Greten, Tim F. Zhao, Fei Gamrekelashvili, Jaba Korangy, Firouzeh Oncoimmunology Author's View The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518530/ /pubmed/23243621 http://dx.doi.org/10.4161/onci.21245 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Greten, Tim F.
Zhao, Fei
Gamrekelashvili, Jaba
Korangy, Firouzeh
Human Th17 cells in patients with cancer: Friends or foe?
title Human Th17 cells in patients with cancer: Friends or foe?
title_full Human Th17 cells in patients with cancer: Friends or foe?
title_fullStr Human Th17 cells in patients with cancer: Friends or foe?
title_full_unstemmed Human Th17 cells in patients with cancer: Friends or foe?
title_short Human Th17 cells in patients with cancer: Friends or foe?
title_sort human th17 cells in patients with cancer: friends or foe?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518530/
https://www.ncbi.nlm.nih.gov/pubmed/23243621
http://dx.doi.org/10.4161/onci.21245
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