Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs

Activated lymphocytes secrete dendritic cell (DC)-activating cytokines including tumor necrosis factor α and interferon γ, and induce Type-1-polarized DCs (DC1s). Lymphocyte-polarized DC1s secrete high levels of biologically active interleukin-12 (IL-12p70) and CXCL10 and show enhanced CTL-inducing...

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Detalles Bibliográficos
Autores principales: Berk, Erik, Kalinski, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518532/
https://www.ncbi.nlm.nih.gov/pubmed/23243623
http://dx.doi.org/10.4161/onci.21295
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author Berk, Erik
Kalinski, Pawel
author_facet Berk, Erik
Kalinski, Pawel
author_sort Berk, Erik
collection PubMed
description Activated lymphocytes secrete dendritic cell (DC)-activating cytokines including tumor necrosis factor α and interferon γ, and induce Type-1-polarized DCs (DC1s). Lymphocyte-polarized DC1s secrete high levels of biologically active interleukin-12 (IL-12p70) and CXCL10 and show enhanced CTL-inducing activity. Our data demonstrate the feasibility of using autologous lymphocytes to enhance the immunogenic properties of DCs in a low-cost clinically-compatible process.
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spelling pubmed-35185322012-12-14 Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs Berk, Erik Kalinski, Pawel Oncoimmunology Author's View Activated lymphocytes secrete dendritic cell (DC)-activating cytokines including tumor necrosis factor α and interferon γ, and induce Type-1-polarized DCs (DC1s). Lymphocyte-polarized DC1s secrete high levels of biologically active interleukin-12 (IL-12p70) and CXCL10 and show enhanced CTL-inducing activity. Our data demonstrate the feasibility of using autologous lymphocytes to enhance the immunogenic properties of DCs in a low-cost clinically-compatible process. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518532/ /pubmed/23243623 http://dx.doi.org/10.4161/onci.21295 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Berk, Erik
Kalinski, Pawel
Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
title Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
title_full Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
title_fullStr Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
title_full_unstemmed Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
title_short Lymphocyte-polarized DC1s: Effective inducers of tumor-specific CTLs
title_sort lymphocyte-polarized dc1s: effective inducers of tumor-specific ctls
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518532/
https://www.ncbi.nlm.nih.gov/pubmed/23243623
http://dx.doi.org/10.4161/onci.21295
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AT kalinskipawel lymphocytepolarizeddc1seffectiveinducersoftumorspecificctls

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