A glypican-3-derived peptide vaccine against hepatocellular carcinoma

The results of a Phase I clinical trial in which a glypican-3 (GPC3)-derived peptide was tested in advanced hepatocellular carcinoma patients point to a strong correlation between immunological and clinical responses. This commentary reviews our fundamental studies and clinical trials on the GPC3-de...

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Autores principales: Sawada, Yu, Sakai, Mayuko, Yoshikawa, Toshiaki, Ofuji, Kazuya, Nakatsura, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518534/
https://www.ncbi.nlm.nih.gov/pubmed/23243625
http://dx.doi.org/10.4161/onci.21351
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author Sawada, Yu
Sakai, Mayuko
Yoshikawa, Toshiaki
Ofuji, Kazuya
Nakatsura, Tetsuya
author_facet Sawada, Yu
Sakai, Mayuko
Yoshikawa, Toshiaki
Ofuji, Kazuya
Nakatsura, Tetsuya
author_sort Sawada, Yu
collection PubMed
description The results of a Phase I clinical trial in which a glypican-3 (GPC3)-derived peptide was tested in advanced hepatocellular carcinoma patients point to a strong correlation between immunological and clinical responses. This commentary reviews our fundamental studies and clinical trials on the GPC3-derived peptide vaccine.
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spelling pubmed-35185342012-12-14 A glypican-3-derived peptide vaccine against hepatocellular carcinoma Sawada, Yu Sakai, Mayuko Yoshikawa, Toshiaki Ofuji, Kazuya Nakatsura, Tetsuya Oncoimmunology Author's View The results of a Phase I clinical trial in which a glypican-3 (GPC3)-derived peptide was tested in advanced hepatocellular carcinoma patients point to a strong correlation between immunological and clinical responses. This commentary reviews our fundamental studies and clinical trials on the GPC3-derived peptide vaccine. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518534/ /pubmed/23243625 http://dx.doi.org/10.4161/onci.21351 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sawada, Yu
Sakai, Mayuko
Yoshikawa, Toshiaki
Ofuji, Kazuya
Nakatsura, Tetsuya
A glypican-3-derived peptide vaccine against hepatocellular carcinoma
title A glypican-3-derived peptide vaccine against hepatocellular carcinoma
title_full A glypican-3-derived peptide vaccine against hepatocellular carcinoma
title_fullStr A glypican-3-derived peptide vaccine against hepatocellular carcinoma
title_full_unstemmed A glypican-3-derived peptide vaccine against hepatocellular carcinoma
title_short A glypican-3-derived peptide vaccine against hepatocellular carcinoma
title_sort glypican-3-derived peptide vaccine against hepatocellular carcinoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518534/
https://www.ncbi.nlm.nih.gov/pubmed/23243625
http://dx.doi.org/10.4161/onci.21351
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