Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma

Cytotoxic lymphocytes and dendritic cells infiltrating human renal cell carcinoma (RCC) are not sufficient to prevent tumor progression. Our studies identified alterations of the immune cell infiltrate as well as some of the underlying mechanisms. This knowledge should facilitate the development of...

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Autores principales: Noessner, Elfriede, Brech, Dorothee, Mendler, Anna N., Masouris, Ilias, Schlenker, Ramona, Prinz, Petra U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518535/
https://www.ncbi.nlm.nih.gov/pubmed/23243626
http://dx.doi.org/10.4161/onci.21356
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author Noessner, Elfriede
Brech, Dorothee
Mendler, Anna N.
Masouris, Ilias
Schlenker, Ramona
Prinz, Petra U.
author_facet Noessner, Elfriede
Brech, Dorothee
Mendler, Anna N.
Masouris, Ilias
Schlenker, Ramona
Prinz, Petra U.
author_sort Noessner, Elfriede
collection PubMed
description Cytotoxic lymphocytes and dendritic cells infiltrating human renal cell carcinoma (RCC) are not sufficient to prevent tumor progression. Our studies identified alterations of the immune cell infiltrate as well as some of the underlying mechanisms. This knowledge should facilitate the development of anti-RCC therapies that achieve better tumor control.
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spelling pubmed-35185352012-12-14 Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma Noessner, Elfriede Brech, Dorothee Mendler, Anna N. Masouris, Ilias Schlenker, Ramona Prinz, Petra U. Oncoimmunology Author's View Cytotoxic lymphocytes and dendritic cells infiltrating human renal cell carcinoma (RCC) are not sufficient to prevent tumor progression. Our studies identified alterations of the immune cell infiltrate as well as some of the underlying mechanisms. This knowledge should facilitate the development of anti-RCC therapies that achieve better tumor control. Landes Bioscience 2012-11-01 /pmc/articles/PMC3518535/ /pubmed/23243626 http://dx.doi.org/10.4161/onci.21356 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Noessner, Elfriede
Brech, Dorothee
Mendler, Anna N.
Masouris, Ilias
Schlenker, Ramona
Prinz, Petra U.
Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
title Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
title_full Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
title_fullStr Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
title_full_unstemmed Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
title_short Intratumoral alterations of dendritic-cell differentiation and CD8(+) T-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
title_sort intratumoral alterations of dendritic-cell differentiation and cd8(+) t-cell anergy are immune escape mechanisms of clear cell renal cell carcinoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518535/
https://www.ncbi.nlm.nih.gov/pubmed/23243626
http://dx.doi.org/10.4161/onci.21356
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