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Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1

PURPOSE: Sigma receptor 1 (σR1) is a non-opioid transmembrane protein that may act as a molecular chaperone at the endoplasmic reticulum–mitochondrial membrane. Ligands for σR1, such as (+)-pentazocine [(+)-PTZ], confer marked retinal neuroprotection in vivo and in vitro. Recently we analyzed the re...

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Detalles Bibliográficos
Autores principales:	Ha, Yonju, Saul, Alan, Tawfik, Amany, Zorrilla, Eric P., Ganapathy, Vadivel, Smith, Sylvia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519370/ https://www.ncbi.nlm.nih.gov/pubmed/23233788

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