CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary vascular dementia caused by mutations in NOTCH3 gene. Pathology is manifested in small- and middle-sized arteries throughout the body, though primarily in cerebral white...

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Detalles Bibliográficos
Autores principales: Tikka, Saara, Peng Ng, Yan, Di Maio, Giuseppe, Mykkänen, Kati, Siitonen, Maija, Lepikhova, Tatiana, Pöyhönen, Minna, Viitanen, Matti, Virtanen, Ismo, Kalimo, Hannu, Baumann, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519411/
https://www.ncbi.nlm.nih.gov/pubmed/22948298
http://dx.doi.org/10.1038/jcbfm.2012.123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519411/
https://www.ncbi.nlm.nih.gov/pubmed/22948298
http://dx.doi.org/10.1038/jcbfm.2012.123

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