Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

BACKGROUND: Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes. The purpose of this study was to investigate whether intrathecal pretreatment with amitriptyline combined with p...

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Detalles Bibliográficos
Autores principales: Cheng, Kuang-I, Wang, Hung-Chen, Chang, Lin-Li, Wang, Fu-Yen, Lai, Chung-Sheng, Chou, Chao-Wen, Tsai, Hung-Pei, Kwan, Aij-Lie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519508/
https://www.ncbi.nlm.nih.gov/pubmed/22720761
http://dx.doi.org/10.1186/1471-2377-12-44

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