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Respiratory viruses from hospitalized children with severe pneumonia in the Philippines

BACKGROUND: Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. METHODS: The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days t...

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Autores principales: Suzuki, Akira, Lupisan, Socorro, Furuse, Yuki, Fuji, Naoko, Saito, Mariko, Tamaki, Raita, Galang, Hazel, Sombrero, Lydia, Mondoy, Melisa, Aniceto, Rapunzel, Olveda, Remigio, Oshitani, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519714/
https://www.ncbi.nlm.nih.gov/pubmed/23092190
http://dx.doi.org/10.1186/1471-2334-12-267
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author Suzuki, Akira
Lupisan, Socorro
Furuse, Yuki
Fuji, Naoko
Saito, Mariko
Tamaki, Raita
Galang, Hazel
Sombrero, Lydia
Mondoy, Melisa
Aniceto, Rapunzel
Olveda, Remigio
Oshitani, Hitoshi
author_facet Suzuki, Akira
Lupisan, Socorro
Furuse, Yuki
Fuji, Naoko
Saito, Mariko
Tamaki, Raita
Galang, Hazel
Sombrero, Lydia
Mondoy, Melisa
Aniceto, Rapunzel
Olveda, Remigio
Oshitani, Hitoshi
author_sort Suzuki, Akira
collection PubMed
description BACKGROUND: Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. METHODS: The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days to 13 years old who were admitted to the Department of Pediatrics with severe pneumonia were enrolled for the study. Upon admission, polymerase chain reaction was performed using nasopharyngeal swabs and blood cultures to detect respiratory viruses and bacteria, respectively. RESULT: Among the 819 patients enrolled, at least one virus was detected in 501 cases (61.2%). In addition, 423 cases were positive for a single virus while bacteria were detected in the blood culture sample of 31 cases. The most commonly detected viruses were human rhinoviruses (n = 189), including types A (n = 103), B (n = 17), and C (n = 69), and respiratory syncytial virus (RSV) (n = 165). Novel viruses such as human metapneumovirus, human coronavirus NL63, human bocavirus, and human polyomaviruses WU and KI were also detected. There were 70 deaths, and one or more viruses were detected in 35 (50%) of these cases. Positivity only for influenza A virus (OR = 4.3, 95% CI = 1.3-14.6) was significantly associated with fatal outcome. From the blood culture, Burkholderia cepacia group (n = 9), Streptococcus pneumoniae (n = 4), Staphylococcus aureus (n = 4), Haemophilus influenzae (n = 1), and Salmonella C1 (n = 1) were also isolated. CONCLUSION: Viruses were commonly detected in children with severe pneumonia in the Philippines. Hence, viral etiologies should be considered while developing better effective strategies to reduce child pneumonia-related deaths in developing countries.
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spelling pubmed-35197142012-12-12 Respiratory viruses from hospitalized children with severe pneumonia in the Philippines Suzuki, Akira Lupisan, Socorro Furuse, Yuki Fuji, Naoko Saito, Mariko Tamaki, Raita Galang, Hazel Sombrero, Lydia Mondoy, Melisa Aniceto, Rapunzel Olveda, Remigio Oshitani, Hitoshi BMC Infect Dis Research Article BACKGROUND: Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. METHODS: The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days to 13 years old who were admitted to the Department of Pediatrics with severe pneumonia were enrolled for the study. Upon admission, polymerase chain reaction was performed using nasopharyngeal swabs and blood cultures to detect respiratory viruses and bacteria, respectively. RESULT: Among the 819 patients enrolled, at least one virus was detected in 501 cases (61.2%). In addition, 423 cases were positive for a single virus while bacteria were detected in the blood culture sample of 31 cases. The most commonly detected viruses were human rhinoviruses (n = 189), including types A (n = 103), B (n = 17), and C (n = 69), and respiratory syncytial virus (RSV) (n = 165). Novel viruses such as human metapneumovirus, human coronavirus NL63, human bocavirus, and human polyomaviruses WU and KI were also detected. There were 70 deaths, and one or more viruses were detected in 35 (50%) of these cases. Positivity only for influenza A virus (OR = 4.3, 95% CI = 1.3-14.6) was significantly associated with fatal outcome. From the blood culture, Burkholderia cepacia group (n = 9), Streptococcus pneumoniae (n = 4), Staphylococcus aureus (n = 4), Haemophilus influenzae (n = 1), and Salmonella C1 (n = 1) were also isolated. CONCLUSION: Viruses were commonly detected in children with severe pneumonia in the Philippines. Hence, viral etiologies should be considered while developing better effective strategies to reduce child pneumonia-related deaths in developing countries. BioMed Central 2012-10-23 /pmc/articles/PMC3519714/ /pubmed/23092190 http://dx.doi.org/10.1186/1471-2334-12-267 Text en Copyright ©2012 Suzuki et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Suzuki, Akira
Lupisan, Socorro
Furuse, Yuki
Fuji, Naoko
Saito, Mariko
Tamaki, Raita
Galang, Hazel
Sombrero, Lydia
Mondoy, Melisa
Aniceto, Rapunzel
Olveda, Remigio
Oshitani, Hitoshi
Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
title Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
title_full Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
title_fullStr Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
title_full_unstemmed Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
title_short Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
title_sort respiratory viruses from hospitalized children with severe pneumonia in the philippines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519714/
https://www.ncbi.nlm.nih.gov/pubmed/23092190
http://dx.doi.org/10.1186/1471-2334-12-267
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