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Respiratory viruses from hospitalized children with severe pneumonia in the Philippines
BACKGROUND: Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. METHODS: The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519714/ https://www.ncbi.nlm.nih.gov/pubmed/23092190 http://dx.doi.org/10.1186/1471-2334-12-267 |
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author | Suzuki, Akira Lupisan, Socorro Furuse, Yuki Fuji, Naoko Saito, Mariko Tamaki, Raita Galang, Hazel Sombrero, Lydia Mondoy, Melisa Aniceto, Rapunzel Olveda, Remigio Oshitani, Hitoshi |
author_facet | Suzuki, Akira Lupisan, Socorro Furuse, Yuki Fuji, Naoko Saito, Mariko Tamaki, Raita Galang, Hazel Sombrero, Lydia Mondoy, Melisa Aniceto, Rapunzel Olveda, Remigio Oshitani, Hitoshi |
author_sort | Suzuki, Akira |
collection | PubMed |
description | BACKGROUND: Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. METHODS: The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days to 13 years old who were admitted to the Department of Pediatrics with severe pneumonia were enrolled for the study. Upon admission, polymerase chain reaction was performed using nasopharyngeal swabs and blood cultures to detect respiratory viruses and bacteria, respectively. RESULT: Among the 819 patients enrolled, at least one virus was detected in 501 cases (61.2%). In addition, 423 cases were positive for a single virus while bacteria were detected in the blood culture sample of 31 cases. The most commonly detected viruses were human rhinoviruses (n = 189), including types A (n = 103), B (n = 17), and C (n = 69), and respiratory syncytial virus (RSV) (n = 165). Novel viruses such as human metapneumovirus, human coronavirus NL63, human bocavirus, and human polyomaviruses WU and KI were also detected. There were 70 deaths, and one or more viruses were detected in 35 (50%) of these cases. Positivity only for influenza A virus (OR = 4.3, 95% CI = 1.3-14.6) was significantly associated with fatal outcome. From the blood culture, Burkholderia cepacia group (n = 9), Streptococcus pneumoniae (n = 4), Staphylococcus aureus (n = 4), Haemophilus influenzae (n = 1), and Salmonella C1 (n = 1) were also isolated. CONCLUSION: Viruses were commonly detected in children with severe pneumonia in the Philippines. Hence, viral etiologies should be considered while developing better effective strategies to reduce child pneumonia-related deaths in developing countries. |
format | Online Article Text |
id | pubmed-3519714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35197142012-12-12 Respiratory viruses from hospitalized children with severe pneumonia in the Philippines Suzuki, Akira Lupisan, Socorro Furuse, Yuki Fuji, Naoko Saito, Mariko Tamaki, Raita Galang, Hazel Sombrero, Lydia Mondoy, Melisa Aniceto, Rapunzel Olveda, Remigio Oshitani, Hitoshi BMC Infect Dis Research Article BACKGROUND: Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. METHODS: The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days to 13 years old who were admitted to the Department of Pediatrics with severe pneumonia were enrolled for the study. Upon admission, polymerase chain reaction was performed using nasopharyngeal swabs and blood cultures to detect respiratory viruses and bacteria, respectively. RESULT: Among the 819 patients enrolled, at least one virus was detected in 501 cases (61.2%). In addition, 423 cases were positive for a single virus while bacteria were detected in the blood culture sample of 31 cases. The most commonly detected viruses were human rhinoviruses (n = 189), including types A (n = 103), B (n = 17), and C (n = 69), and respiratory syncytial virus (RSV) (n = 165). Novel viruses such as human metapneumovirus, human coronavirus NL63, human bocavirus, and human polyomaviruses WU and KI were also detected. There were 70 deaths, and one or more viruses were detected in 35 (50%) of these cases. Positivity only for influenza A virus (OR = 4.3, 95% CI = 1.3-14.6) was significantly associated with fatal outcome. From the blood culture, Burkholderia cepacia group (n = 9), Streptococcus pneumoniae (n = 4), Staphylococcus aureus (n = 4), Haemophilus influenzae (n = 1), and Salmonella C1 (n = 1) were also isolated. CONCLUSION: Viruses were commonly detected in children with severe pneumonia in the Philippines. Hence, viral etiologies should be considered while developing better effective strategies to reduce child pneumonia-related deaths in developing countries. BioMed Central 2012-10-23 /pmc/articles/PMC3519714/ /pubmed/23092190 http://dx.doi.org/10.1186/1471-2334-12-267 Text en Copyright ©2012 Suzuki et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Suzuki, Akira Lupisan, Socorro Furuse, Yuki Fuji, Naoko Saito, Mariko Tamaki, Raita Galang, Hazel Sombrero, Lydia Mondoy, Melisa Aniceto, Rapunzel Olveda, Remigio Oshitani, Hitoshi Respiratory viruses from hospitalized children with severe pneumonia in the Philippines |
title | Respiratory viruses from hospitalized children with severe pneumonia in the Philippines |
title_full | Respiratory viruses from hospitalized children with severe pneumonia in the Philippines |
title_fullStr | Respiratory viruses from hospitalized children with severe pneumonia in the Philippines |
title_full_unstemmed | Respiratory viruses from hospitalized children with severe pneumonia in the Philippines |
title_short | Respiratory viruses from hospitalized children with severe pneumonia in the Philippines |
title_sort | respiratory viruses from hospitalized children with severe pneumonia in the philippines |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519714/ https://www.ncbi.nlm.nih.gov/pubmed/23092190 http://dx.doi.org/10.1186/1471-2334-12-267 |
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