Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

BACKGROUND: Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD). FUS accumulates in neuronal cytoplasmic inclusions (NCIs) in ALS patients with FUS mutations. FUS is...

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Detalles Bibliográficos
Autores principales: Verbeeck, Christophe, Deng, Qiudong, DeJesus-Hernandez, Mariely, Taylor, Georgia, Ceballos-Diaz, Carolina, Kocerha, Jannet, Golde, Todd, Das, Pritam, Rademakers, Rosa, Dickson, Dennis W, Kukar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519790/
https://www.ncbi.nlm.nih.gov/pubmed/23046583
http://dx.doi.org/10.1186/1750-1326-7-53

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