Cargando…
DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy
BACKGROUND: More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection rectopexy the most commonly used abdominal procedure. Recurrences seem more comm...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519813/ https://www.ncbi.nlm.nih.gov/pubmed/22931552 http://dx.doi.org/10.1186/1745-6215-13-155 |
_version_ | 1782252743182778368 |
---|---|
author | Rothenhoefer, Simone Herrle, Florian Herold, Alexander Joos, Andreas Bussen, Dieter Kieser, Meinhard Schiller, Petra Klose, Christina Seiler, Christoph M Kienle, Peter Post, Stefan |
author_facet | Rothenhoefer, Simone Herrle, Florian Herold, Alexander Joos, Andreas Bussen, Dieter Kieser, Meinhard Schiller, Petra Klose, Christina Seiler, Christoph M Kienle, Peter Post, Stefan |
author_sort | Rothenhoefer, Simone |
collection | PubMed |
description | BACKGROUND: More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection rectopexy the most commonly used abdominal procedure. Recurrences seem more common after perineal compared to abdominal techniques, but the latter may carry a higher risk of peri- and postoperative morbidity and mortality. METHODS/DESIGN: DeloRes is a randomized, controlled, observer-blinded multicenter trial with two parallel groups. Patients with a full-thickness rectal prolapse (third degree prolapse), considered eligible for both operative methods are included. The primary outcome is time to recurrence of full-thickness rectal prolapse during the 24 months following primary surgery. Secondary endpoints are time to and incidence of recurrence of full-thickness rectal prolapse during the 5-year follow-up, duration of surgery, morbidity, hospital stay, quality of life, constipation, and fecal incontinence. A meta-analysis was done on the basis of the available data on recurrence rates from 17 publications comprising 1,140 patients. Based on the results of a meta-analysis it is assumed that the recurrence rate after 2 years is 20% for Delorme’s procedure and 5% for resection rectopexy. Considering a rate of lost to follow-up without recurrence of 30% a total of 130 patients (2 x 65 patients) was calculated as an adequate sample size to assure a power of 80% for the confirmatory analysis. DISCUSSION: The DeloRes Trial will clarify which procedure results in a smaller recurrence rate but also give information on how morbidity and functional results compare. TRIAL REGISTRATION: German Clinical Trial Number DRKS00000482 |
format | Online Article Text |
id | pubmed-3519813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35198132012-12-12 DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy Rothenhoefer, Simone Herrle, Florian Herold, Alexander Joos, Andreas Bussen, Dieter Kieser, Meinhard Schiller, Petra Klose, Christina Seiler, Christoph M Kienle, Peter Post, Stefan Trials Study Protocol BACKGROUND: More than 100 surgical approaches to treat rectal prolapse have been described. These can be done through the perineum or transabdominally. Delorme’s procedure is the most frequently used perineal, resection rectopexy the most commonly used abdominal procedure. Recurrences seem more common after perineal compared to abdominal techniques, but the latter may carry a higher risk of peri- and postoperative morbidity and mortality. METHODS/DESIGN: DeloRes is a randomized, controlled, observer-blinded multicenter trial with two parallel groups. Patients with a full-thickness rectal prolapse (third degree prolapse), considered eligible for both operative methods are included. The primary outcome is time to recurrence of full-thickness rectal prolapse during the 24 months following primary surgery. Secondary endpoints are time to and incidence of recurrence of full-thickness rectal prolapse during the 5-year follow-up, duration of surgery, morbidity, hospital stay, quality of life, constipation, and fecal incontinence. A meta-analysis was done on the basis of the available data on recurrence rates from 17 publications comprising 1,140 patients. Based on the results of a meta-analysis it is assumed that the recurrence rate after 2 years is 20% for Delorme’s procedure and 5% for resection rectopexy. Considering a rate of lost to follow-up without recurrence of 30% a total of 130 patients (2 x 65 patients) was calculated as an adequate sample size to assure a power of 80% for the confirmatory analysis. DISCUSSION: The DeloRes Trial will clarify which procedure results in a smaller recurrence rate but also give information on how morbidity and functional results compare. TRIAL REGISTRATION: German Clinical Trial Number DRKS00000482 BioMed Central 2012-08-29 /pmc/articles/PMC3519813/ /pubmed/22931552 http://dx.doi.org/10.1186/1745-6215-13-155 Text en Copyright ©2012 Rothenhoefer et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Study Protocol Rothenhoefer, Simone Herrle, Florian Herold, Alexander Joos, Andreas Bussen, Dieter Kieser, Meinhard Schiller, Petra Klose, Christina Seiler, Christoph M Kienle, Peter Post, Stefan DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
title | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
title_full | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
title_fullStr | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
title_full_unstemmed | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
title_short | DeloRes trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - Delorme’s procedure versus resection rectopexy |
title_sort | delores trial: study protocol for a randomized trial comparing two standardized surgical approaches in rectal prolapse - delorme’s procedure versus resection rectopexy |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519813/ https://www.ncbi.nlm.nih.gov/pubmed/22931552 http://dx.doi.org/10.1186/1745-6215-13-155 |
work_keys_str_mv | AT rothenhoefersimone delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT herrleflorian delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT heroldalexander delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT joosandreas delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT bussendieter delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT kiesermeinhard delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT schillerpetra delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT klosechristina delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT seilerchristophm delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT kienlepeter delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy AT poststefan delorestrialstudyprotocolforarandomizedtrialcomparingtwostandardizedsurgicalapproachesinrectalprolapsedelormesprocedureversusresectionrectopexy |