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Algorithmic Modeling Quantifies the Complementary Contribution of Metabolic Inhibitions to Gemcitabine Efficacy

Gemcitabine (2,2-difluorodeoxycytidine, dFdC) is a prodrug widely used for treating various carcinomas. Gemcitabine exerts its clinical effect by depleting the deoxyribonucleotide pools, and incorporating its triphosphate metabolite (dFdC-TP) into DNA, thereby inhibiting DNA synthesis. This process...

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Detalles Bibliográficos
Autores principales:	Kahramanoğullari, Ozan, Fantaccini, Gianluca, Lecca, Paola, Morpurgo, Daniele, Priami, Corrado
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519828/ https://www.ncbi.nlm.nih.gov/pubmed/23239976 http://dx.doi.org/10.1371/journal.pone.0050176

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