Utility of an improved model of amyloid-beta (Aβ(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

BACKGROUND: The definitive indicator of Alzheimer’s disease (AD) pathology is the profuse accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based models have been proposed for high throughput drug screening for potential therapeutic benefit in diseases of protein misfolding....

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Detalles Bibliográficos
Autores principales: McColl, Gawain, Roberts, Blaine R, Pukala, Tara L, Kenche, Vijaya B, Roberts, Christine M, Link, Christopher D, Ryan, Timothy M, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I, Cherny, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519830/
https://www.ncbi.nlm.nih.gov/pubmed/23171715
http://dx.doi.org/10.1186/1750-1326-7-57

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