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What Can We Learn from the Evolution of Protein-Ligand Interactions to Aid the Design of New Therapeutics?
Efforts to increase affinity in the design of new therapeutic molecules have tended to lead to greater lipophilicity, a factor that is generally agreed to be contributing to the low success rate of new drug candidates. Our aim is to provide a structural perspective to the study of lipophilic efficie...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519888/ https://www.ncbi.nlm.nih.gov/pubmed/23240060 http://dx.doi.org/10.1371/journal.pone.0051742 |