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LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

BACKGROUND: The Aβ peptide that accumulates in Alzheimer’s disease (AD) is derived from amyloid precursor protein (APP) following proteolysis by β- and γ-secretases. Substantial evidence indicates that alterations in APP trafficking within the secretory and endocytic pathways directly impact the int...

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Detalles Bibliográficos
Autores principales:	Brodeur, Julie, Thériault, Caroline, Lessard-Beaudoin, Mélissa, Marcil, Alexandre, Dahan, Sophie, Lavoie, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520120/ https://www.ncbi.nlm.nih.gov/pubmed/22734645 http://dx.doi.org/10.1186/1750-1326-7-31

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