TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4(+) T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells most efficiently is the dendritic cell (DC). As such, we sho...

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Detalles Bibliográficos
Autores principales: Mellanby, Richard J, Cambrook, Helen, Turner, Darryl G, O’Connor, Richard A, Leech, Melanie D, Kurschus, Florian C, MacDonald, Andrew S, Arnold, Bernd, Anderton, Stephen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520704/
https://www.ncbi.nlm.nih.gov/pubmed/23111144
http://dx.doi.org/10.1186/1742-2094-9-248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520704/
https://www.ncbi.nlm.nih.gov/pubmed/23111144
http://dx.doi.org/10.1186/1742-2094-9-248

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