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Impact of Chikungunya on Health Related Quality of Life Chennai, South India

BACKGROUND: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Fu...

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Autores principales: Ramachandran, Vidya, Malaisamy, Muniyandi, Ponnaiah, Manickam, Kaliaperuaml, Kanagasabai, Vadivoo, Selvaraj, Gupte, Mohan Digambar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520806/
https://www.ncbi.nlm.nih.gov/pubmed/23251562
http://dx.doi.org/10.1371/journal.pone.0051519
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author Ramachandran, Vidya
Malaisamy, Muniyandi
Ponnaiah, Manickam
Kaliaperuaml, Kanagasabai
Vadivoo, Selvaraj
Gupte, Mohan Digambar
author_facet Ramachandran, Vidya
Malaisamy, Muniyandi
Ponnaiah, Manickam
Kaliaperuaml, Kanagasabai
Vadivoo, Selvaraj
Gupte, Mohan Digambar
author_sort Ramachandran, Vidya
collection PubMed
description BACKGROUND: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Further, we determined factors associated with clinical recovery among C-CHIKV patients. METHODS: We followed-up 403 of 425 adult C-CHIKV cases identified during an outbreak. On the basis of a reassessment of their current clinical status through self-reporting, we categorized them as ‘clinically recovered’ (n = 308) or ‘not recovered’ (n = 95). In the absence of base-line information on HRQoL, we included a comparison group of healthy normal’s recruited by frequency matching for age and sex from the neighbourhood (n = 308). We conducted a comparative cross-sectional study of these three groups and estimated HRQoL scores using SF-36 questionnaire. We tested the differences in the median scores by Kruksall Wallistest. We identified factors associated with ‘recovery’ as compared to not-recovery by calculating Adjusted Odds Ratio (AOR) and 95% Confidence Intervals through multiple regression analysis. RESULTS: As compared to ‘normals’, we observed a 20 and five-fold reductions in HRQoL scores for C-CHIKV patients ‘not recovered’ and ‘recovered’ respectively. Differences in HRQoL scores for all the domains were statistically significant between three groups (p<0·001). Younger age, male, absence of rashes, affliction of less than five types of joints and two weeks of joint swelling were significantly associated with recovery. HRQoL scores improved with time among those ‘clinically recovered’. CONCLUSION: This study provides evidence for sharp reductions in quality of life not only during active C-CHIKV associated illness but also for several months after clinical recovery compared to healthy normals. This has implications for developing intervention programmes in countries with high risk of CHIKV outbreaks.
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spelling pubmed-35208062012-12-18 Impact of Chikungunya on Health Related Quality of Life Chennai, South India Ramachandran, Vidya Malaisamy, Muniyandi Ponnaiah, Manickam Kaliaperuaml, Kanagasabai Vadivoo, Selvaraj Gupte, Mohan Digambar PLoS One Research Article BACKGROUND: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Further, we determined factors associated with clinical recovery among C-CHIKV patients. METHODS: We followed-up 403 of 425 adult C-CHIKV cases identified during an outbreak. On the basis of a reassessment of their current clinical status through self-reporting, we categorized them as ‘clinically recovered’ (n = 308) or ‘not recovered’ (n = 95). In the absence of base-line information on HRQoL, we included a comparison group of healthy normal’s recruited by frequency matching for age and sex from the neighbourhood (n = 308). We conducted a comparative cross-sectional study of these three groups and estimated HRQoL scores using SF-36 questionnaire. We tested the differences in the median scores by Kruksall Wallistest. We identified factors associated with ‘recovery’ as compared to not-recovery by calculating Adjusted Odds Ratio (AOR) and 95% Confidence Intervals through multiple regression analysis. RESULTS: As compared to ‘normals’, we observed a 20 and five-fold reductions in HRQoL scores for C-CHIKV patients ‘not recovered’ and ‘recovered’ respectively. Differences in HRQoL scores for all the domains were statistically significant between three groups (p<0·001). Younger age, male, absence of rashes, affliction of less than five types of joints and two weeks of joint swelling were significantly associated with recovery. HRQoL scores improved with time among those ‘clinically recovered’. CONCLUSION: This study provides evidence for sharp reductions in quality of life not only during active C-CHIKV associated illness but also for several months after clinical recovery compared to healthy normals. This has implications for developing intervention programmes in countries with high risk of CHIKV outbreaks. Public Library of Science 2012-12-12 /pmc/articles/PMC3520806/ /pubmed/23251562 http://dx.doi.org/10.1371/journal.pone.0051519 Text en © 2012 Ramachandran et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ramachandran, Vidya
Malaisamy, Muniyandi
Ponnaiah, Manickam
Kaliaperuaml, Kanagasabai
Vadivoo, Selvaraj
Gupte, Mohan Digambar
Impact of Chikungunya on Health Related Quality of Life Chennai, South India
title Impact of Chikungunya on Health Related Quality of Life Chennai, South India
title_full Impact of Chikungunya on Health Related Quality of Life Chennai, South India
title_fullStr Impact of Chikungunya on Health Related Quality of Life Chennai, South India
title_full_unstemmed Impact of Chikungunya on Health Related Quality of Life Chennai, South India
title_short Impact of Chikungunya on Health Related Quality of Life Chennai, South India
title_sort impact of chikungunya on health related quality of life chennai, south india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520806/
https://www.ncbi.nlm.nih.gov/pubmed/23251562
http://dx.doi.org/10.1371/journal.pone.0051519
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