Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

Testicular Germ Cell Tumors (TGCT) and patient-derived cell lines are extremely sensitive to cisplatin and other interstrand cross-link (ICL) inducing agents. Nevertheless, a subset of TGCTs are either innately resistant or acquire resistance to cisplatin during treatment. Understanding the mechanis...

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Detalles Bibliográficos
Autores principales: Cavallo, Francesca, Graziani, Grazia, Antinozzi, Cristina, Feldman, Darren R., Houldsworth, Jane, Bosl, George J., Chaganti, Raju S. K., Moynahan, Mary Ellen, Jasin, Maria, Barchi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520950/
https://www.ncbi.nlm.nih.gov/pubmed/23251575
http://dx.doi.org/10.1371/journal.pone.0051563

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