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Binding Modes of Peptidomimetics Designed to Inhibit STAT3
STAT3 is a transcription factor that has been found to be constitutively activated in a number of human cancers. Dimerization of STAT3 via its SH2 domain and the subsequent translocation of the dimer to the nucleus leads to transcription of anti-apoptotic genes. Prevention of the dimerization is thu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520966/ https://www.ncbi.nlm.nih.gov/pubmed/23251591 http://dx.doi.org/10.1371/journal.pone.0051603 |