Novel In Vivo Imaging Analysis of an Inner Ear Drug Delivery System in Mice: Comparison of Inner Ear Drug Concentrations over Time after Transtympanic and Systemic Injections

OBJECTIVE: Systemic steroid injections are used to treat idiopathic sudden-onset sensorineural hearing loss (ISSHL) and some inner ear disorders. Recent studies show that transtympanic (TT) steroid injections are effective for treating ISSHL. As in vivo monitoring of drug delivery dynamics for inner...

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Detalles Bibliográficos
Autores principales: Kanzaki, Sho, Fujioka, Masato, Yasuda, Akimasa, Shibata, Shinsuke, Nakamura, Masaya, Okano, Hirotaka James, Ogawa, Kaoru, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520978/
https://www.ncbi.nlm.nih.gov/pubmed/23251331
http://dx.doi.org/10.1371/journal.pone.0048480

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