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Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress

Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological stress ulcer (CPSU)...

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Autores principales: Zhang, Shuang, Xu, Zhiwei, Gao, Yan, Wu, Yonghong, Li, Zhihui, Liu, Haifeng, Zhang, Chenggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521024/
https://www.ncbi.nlm.nih.gov/pubmed/23251441
http://dx.doi.org/10.1371/journal.pone.0051148
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author Zhang, Shuang
Xu, Zhiwei
Gao, Yan
Wu, Yonghong
Li, Zhihui
Liu, Haifeng
Zhang, Chenggang
author_facet Zhang, Shuang
Xu, Zhiwei
Gao, Yan
Wu, Yonghong
Li, Zhihui
Liu, Haifeng
Zhang, Chenggang
author_sort Zhang, Shuang
collection PubMed
description Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological stress ulcer (CPSU) and water immersion restrain stress models in rats. Our data showed that the ulcer index of the animals after CSD exposure was significantly higher than that of controls. Depression-like behaviors were observed in rat after CPSU exposure. Fluoxetine hydrochloride significantly reduced the ulcer index of rats exposed to CPSU stress, while ranitidine inhibited depression-like behavior of the animals in CSD group. The ulcer index of rats administered with mifepristone after CPSU stress was markedly reduced compared to CPSU group, although there was no significant difference in the depression-like behavior between mifepristone-treated CSD group and naive controls. We also found that the rats exposed to CPSU or CSD stress displayed a lower level of corticosterone than naive controls, however, the acute stress (AS) group showed an opposite result. Additionally, in order to study the relevance of H(2) receptors and depression, we treated the CSD group with cimetidine and famotidine respectively. The data showed that cimetidine inhibited depression-like behavior in CSD rats, and famotidine had no impact on depression. Overall our data suggested that the hypothalamic-pituitary-adrenal (HPA) axis dysfunction may be the key role in triggering depression and stress ulcer. Acid-suppressing drugs and antidepressants could be used for treatment of depression and stress ulcer respectively. The occurrence of depression might be inhibited by blocking the central H(2) receptors.
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spelling pubmed-35210242012-12-18 Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress Zhang, Shuang Xu, Zhiwei Gao, Yan Wu, Yonghong Li, Zhihui Liu, Haifeng Zhang, Chenggang PLoS One Research Article Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological stress ulcer (CPSU) and water immersion restrain stress models in rats. Our data showed that the ulcer index of the animals after CSD exposure was significantly higher than that of controls. Depression-like behaviors were observed in rat after CPSU exposure. Fluoxetine hydrochloride significantly reduced the ulcer index of rats exposed to CPSU stress, while ranitidine inhibited depression-like behavior of the animals in CSD group. The ulcer index of rats administered with mifepristone after CPSU stress was markedly reduced compared to CPSU group, although there was no significant difference in the depression-like behavior between mifepristone-treated CSD group and naive controls. We also found that the rats exposed to CPSU or CSD stress displayed a lower level of corticosterone than naive controls, however, the acute stress (AS) group showed an opposite result. Additionally, in order to study the relevance of H(2) receptors and depression, we treated the CSD group with cimetidine and famotidine respectively. The data showed that cimetidine inhibited depression-like behavior in CSD rats, and famotidine had no impact on depression. Overall our data suggested that the hypothalamic-pituitary-adrenal (HPA) axis dysfunction may be the key role in triggering depression and stress ulcer. Acid-suppressing drugs and antidepressants could be used for treatment of depression and stress ulcer respectively. The occurrence of depression might be inhibited by blocking the central H(2) receptors. Public Library of Science 2012-12-12 /pmc/articles/PMC3521024/ /pubmed/23251441 http://dx.doi.org/10.1371/journal.pone.0051148 Text en © 2012 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Shuang
Xu, Zhiwei
Gao, Yan
Wu, Yonghong
Li, Zhihui
Liu, Haifeng
Zhang, Chenggang
Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress
title Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress
title_full Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress
title_fullStr Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress
title_full_unstemmed Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress
title_short Bidirectional Crosstalk between Stress-Induced Gastric Ulcer and Depression under Chronic Stress
title_sort bidirectional crosstalk between stress-induced gastric ulcer and depression under chronic stress
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521024/
https://www.ncbi.nlm.nih.gov/pubmed/23251441
http://dx.doi.org/10.1371/journal.pone.0051148
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