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Mechanisms of arterial remodeling: lessons from genetic diseases

Vascular disease is still the leading cause of morbidity and mortality in the Western world, and the primary cause of myocardial infarction, stroke, and ischemia. The biology of vascular disease is complex and still poorly understood in terms of causes and consequences. Vascular function is determin...

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Autores principales: van Varik, Bernard J., Rennenberg, Roger J. M. W., Reutelingsperger, Chris P., Kroon, Abraham A., de Leeuw, Peter W., Schurgers, Leon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521155/
https://www.ncbi.nlm.nih.gov/pubmed/23248645
http://dx.doi.org/10.3389/fgene.2012.00290
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author van Varik, Bernard J.
Rennenberg, Roger J. M. W.
Reutelingsperger, Chris P.
Kroon, Abraham A.
de Leeuw, Peter W.
Schurgers, Leon J.
author_facet van Varik, Bernard J.
Rennenberg, Roger J. M. W.
Reutelingsperger, Chris P.
Kroon, Abraham A.
de Leeuw, Peter W.
Schurgers, Leon J.
author_sort van Varik, Bernard J.
collection PubMed
description Vascular disease is still the leading cause of morbidity and mortality in the Western world, and the primary cause of myocardial infarction, stroke, and ischemia. The biology of vascular disease is complex and still poorly understood in terms of causes and consequences. Vascular function is determined by structural and functional properties of the arterial vascular wall. Arterial stiffness, that is a pathological alteration of the vascular wall, ultimately results in target-organ damage and increased mortality. Arterial remodeling is accelerated under conditions that adversely affect the balance between arterial function and structure such as hypertension, atherosclerosis, diabetes mellitus, chronic kidney disease, inflammatory disease, lifestyle aspects (smoking), drugs (vitamin K antagonists), and genetic abnormalities [e.g., pseudoxanthoma elasticum (PXE), Marfan's disease]. The aim of this review is to provide an overview of the complex mechanisms and different factors that underlie arterial remodeling, learning from single gene defect diseases like PXE, and PXE-like, Marfan's disease and Keutel syndrome in vascular remodeling.
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spelling pubmed-35211552012-12-17 Mechanisms of arterial remodeling: lessons from genetic diseases van Varik, Bernard J. Rennenberg, Roger J. M. W. Reutelingsperger, Chris P. Kroon, Abraham A. de Leeuw, Peter W. Schurgers, Leon J. Front Genet Physiology Vascular disease is still the leading cause of morbidity and mortality in the Western world, and the primary cause of myocardial infarction, stroke, and ischemia. The biology of vascular disease is complex and still poorly understood in terms of causes and consequences. Vascular function is determined by structural and functional properties of the arterial vascular wall. Arterial stiffness, that is a pathological alteration of the vascular wall, ultimately results in target-organ damage and increased mortality. Arterial remodeling is accelerated under conditions that adversely affect the balance between arterial function and structure such as hypertension, atherosclerosis, diabetes mellitus, chronic kidney disease, inflammatory disease, lifestyle aspects (smoking), drugs (vitamin K antagonists), and genetic abnormalities [e.g., pseudoxanthoma elasticum (PXE), Marfan's disease]. The aim of this review is to provide an overview of the complex mechanisms and different factors that underlie arterial remodeling, learning from single gene defect diseases like PXE, and PXE-like, Marfan's disease and Keutel syndrome in vascular remodeling. Frontiers Media S.A. 2012-12-13 /pmc/articles/PMC3521155/ /pubmed/23248645 http://dx.doi.org/10.3389/fgene.2012.00290 Text en Copyright © 2012 van Varik, Rennenberg, Reutelingsperger, Kroon, de Leeuw and Schurgers. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
van Varik, Bernard J.
Rennenberg, Roger J. M. W.
Reutelingsperger, Chris P.
Kroon, Abraham A.
de Leeuw, Peter W.
Schurgers, Leon J.
Mechanisms of arterial remodeling: lessons from genetic diseases
title Mechanisms of arterial remodeling: lessons from genetic diseases
title_full Mechanisms of arterial remodeling: lessons from genetic diseases
title_fullStr Mechanisms of arterial remodeling: lessons from genetic diseases
title_full_unstemmed Mechanisms of arterial remodeling: lessons from genetic diseases
title_short Mechanisms of arterial remodeling: lessons from genetic diseases
title_sort mechanisms of arterial remodeling: lessons from genetic diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521155/
https://www.ncbi.nlm.nih.gov/pubmed/23248645
http://dx.doi.org/10.3389/fgene.2012.00290
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