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Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression

BACKGROUND: The foetal origins hypothesis suggests an association between low birth weight and later depression, yet evidence supporting this association has been inconsistent. METHOD: We systematically reviewed evidence for an association between low birth weight and adult depression or psychologic...

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Detalles Bibliográficos
Autores principales: Wojcik, W., Lee, W., Colman, I., Hardy, R., Hotopf, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521225/
https://www.ncbi.nlm.nih.gov/pubmed/22717127
http://dx.doi.org/10.1017/S0033291712000682
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author Wojcik, W.
Lee, W.
Colman, I.
Hardy, R.
Hotopf, M.
author_facet Wojcik, W.
Lee, W.
Colman, I.
Hardy, R.
Hotopf, M.
author_sort Wojcik, W.
collection PubMed
description BACKGROUND: The foetal origins hypothesis suggests an association between low birth weight and later depression, yet evidence supporting this association has been inconsistent. METHOD: We systematically reviewed evidence for an association between low birth weight and adult depression or psychological distress in the general population by meta-analysis. We searched EMBASE, Medline, PsycINFO and ISI Web of Science for studies reporting observational data with low birth weight as the exposure and self- or clinician-rated depression or psychological distress measures as an outcome. Selective studies of exposures such as famine or outcomes such as severe illness only were excluded. Altogether,1454 studies were screened for relevance, 26 were included in the qualitative synthesis, 18 were included in the meta-analysis. A random effects meta-analysis method was used to obtain a pooled estimate of effect size. RESULTS: The odds of depression or psychological distress was greater for those of low birth weight (<2500 g) compared to those of normal birth weight (>2500 g) or greater [odds ratio (OR) 1.15, 95% confidence intervals (CI) 1.00–1.32]. However, this association became non-significant after trim-and-fill correction for publication bias (OR 1.08, 95% CI 0.92–1.27). Using meta-regression, no differences in effect size were observed by gender, outcome measure of depression or psychological distress, or whether the effect size was adjusted for possible confounders. CONCLUSIONS: We found evidence to support a weak association between low birth weight and later depression or psychological distress, which may be due to publication bias. It remains possible that the association may vary according to severity of symptoms or other factors.
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spelling pubmed-35212252013-01-28 Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression Wojcik, W. Lee, W. Colman, I. Hardy, R. Hotopf, M. Psychol Med Review Article BACKGROUND: The foetal origins hypothesis suggests an association between low birth weight and later depression, yet evidence supporting this association has been inconsistent. METHOD: We systematically reviewed evidence for an association between low birth weight and adult depression or psychological distress in the general population by meta-analysis. We searched EMBASE, Medline, PsycINFO and ISI Web of Science for studies reporting observational data with low birth weight as the exposure and self- or clinician-rated depression or psychological distress measures as an outcome. Selective studies of exposures such as famine or outcomes such as severe illness only were excluded. Altogether,1454 studies were screened for relevance, 26 were included in the qualitative synthesis, 18 were included in the meta-analysis. A random effects meta-analysis method was used to obtain a pooled estimate of effect size. RESULTS: The odds of depression or psychological distress was greater for those of low birth weight (<2500 g) compared to those of normal birth weight (>2500 g) or greater [odds ratio (OR) 1.15, 95% confidence intervals (CI) 1.00–1.32]. However, this association became non-significant after trim-and-fill correction for publication bias (OR 1.08, 95% CI 0.92–1.27). Using meta-regression, no differences in effect size were observed by gender, outcome measure of depression or psychological distress, or whether the effect size was adjusted for possible confounders. CONCLUSIONS: We found evidence to support a weak association between low birth weight and later depression or psychological distress, which may be due to publication bias. It remains possible that the association may vary according to severity of symptoms or other factors. Cambridge University Press 2013-01 2012-04-13 /pmc/articles/PMC3521225/ /pubmed/22717127 http://dx.doi.org/10.1017/S0033291712000682 Text en Copyright © Cambridge University Press 2012 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>. The written permission of Cambridge University Press must be obtained for commercial re-use.
spellingShingle Review Article
Wojcik, W.
Lee, W.
Colman, I.
Hardy, R.
Hotopf, M.
Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression
title Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression
title_full Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression
title_fullStr Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression
title_full_unstemmed Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression
title_short Foetal origins of depression? A systematic review and meta-analysis of low birth weight and later depression
title_sort foetal origins of depression? a systematic review and meta-analysis of low birth weight and later depression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521225/
https://www.ncbi.nlm.nih.gov/pubmed/22717127
http://dx.doi.org/10.1017/S0033291712000682
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