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A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays
Diffuse reflectance spectroscopy (DRS) is a well-established method to quantitatively distinguish between benign and cancerous tissue for tumor margin assessment. Current multipixel DRS margin assessment tools are bulky fiber-based probes that have limited scalability. Reported herein is a new appro...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521310/ https://www.ncbi.nlm.nih.gov/pubmed/23243571 http://dx.doi.org/10.1364/BOE.3.003211 |
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author | Dhar, Sulochana Lo, Justin Y. Palmer, Gregory M. Brooke, Martin A. Nichols, Brandon S. Yu, Bing Ramanujam, Nirmala Jokerst, Nan M. |
author_facet | Dhar, Sulochana Lo, Justin Y. Palmer, Gregory M. Brooke, Martin A. Nichols, Brandon S. Yu, Bing Ramanujam, Nirmala Jokerst, Nan M. |
author_sort | Dhar, Sulochana |
collection | PubMed |
description | Diffuse reflectance spectroscopy (DRS) is a well-established method to quantitatively distinguish between benign and cancerous tissue for tumor margin assessment. Current multipixel DRS margin assessment tools are bulky fiber-based probes that have limited scalability. Reported herein is a new approach to multipixel DRS probe design, which utilizes direct detection of the DRS signal by using optimized custom photodetectors in direct contact with the tissue. This first fiberless DRS imaging system for tumor margin assessment consists of a 4 × 4 array of annular silicon photodetectors and a constrained free-space light delivery tube optimized to deliver light across a 256 mm(2) imaging area. This system has 4.5 mm spatial resolution. The signal-to-noise ratio measured for normal and malignant breast tissue-mimicking phantoms was 35 dB to 45 dB for λ = 470 nm to 600 nm. |
format | Online Article Text |
id | pubmed-3521310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-35213102012-12-14 A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays Dhar, Sulochana Lo, Justin Y. Palmer, Gregory M. Brooke, Martin A. Nichols, Brandon S. Yu, Bing Ramanujam, Nirmala Jokerst, Nan M. Biomed Opt Express Clinical Instrumentation Diffuse reflectance spectroscopy (DRS) is a well-established method to quantitatively distinguish between benign and cancerous tissue for tumor margin assessment. Current multipixel DRS margin assessment tools are bulky fiber-based probes that have limited scalability. Reported herein is a new approach to multipixel DRS probe design, which utilizes direct detection of the DRS signal by using optimized custom photodetectors in direct contact with the tissue. This first fiberless DRS imaging system for tumor margin assessment consists of a 4 × 4 array of annular silicon photodetectors and a constrained free-space light delivery tube optimized to deliver light across a 256 mm(2) imaging area. This system has 4.5 mm spatial resolution. The signal-to-noise ratio measured for normal and malignant breast tissue-mimicking phantoms was 35 dB to 45 dB for λ = 470 nm to 600 nm. Optical Society of America 2012-11-08 /pmc/articles/PMC3521310/ /pubmed/23243571 http://dx.doi.org/10.1364/BOE.3.003211 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Clinical Instrumentation Dhar, Sulochana Lo, Justin Y. Palmer, Gregory M. Brooke, Martin A. Nichols, Brandon S. Yu, Bing Ramanujam, Nirmala Jokerst, Nan M. A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
title | A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
title_full | A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
title_fullStr | A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
title_full_unstemmed | A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
title_short | A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
title_sort | diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays |
topic | Clinical Instrumentation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521310/ https://www.ncbi.nlm.nih.gov/pubmed/23243571 http://dx.doi.org/10.1364/BOE.3.003211 |
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