Cargando…
Effects of body position on the ventilatory response to hypercapnia
Effect of posture on the hypercapnic ventilatory response was studied on the anaesthetized rats by using rebreathing techniques in the supine and head-down positions. There were no statistically significant alterations in tidal volume, frequency, minute ventilation, and P(ET)CO(2 )between the head-d...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521349/ https://www.ncbi.nlm.nih.gov/pubmed/20156728 http://dx.doi.org/10.1186/2047-783X-14-S4-63 |
_version_ | 1782252937027780608 |
---|---|
author | Donina, Zh A Danilova, GA Aleksandrova, NP |
author_facet | Donina, Zh A Danilova, GA Aleksandrova, NP |
author_sort | Donina, Zh A |
collection | PubMed |
description | Effect of posture on the hypercapnic ventilatory response was studied on the anaesthetized rats by using rebreathing techniques in the supine and head-down positions. There were no statistically significant alterations in tidal volume, frequency, minute ventilation, and P(ET)CO(2 )between the head-down and supine positions during breathing at rest. However, the esophageal pressure inspiratory swings were significantly greater in the head-down compared with supine position. Moreover, we found that body position did not affect the hypercapnic ventilatory response, but did affect the relationship between inspiratory driving pressure and the increase of end tidal PCO(2). Greater inspiratory pressure is required to maintain the same level of the ventilatory response to hypercapnia in the horizontal position with the head-down. We believe that the discrepancy between postural alterations in the hypercapnic ventilatory and pressure responses is presumably a result of decreased lung compliance and increased airflow impedance of respiratory system in the head-down position. |
format | Online Article Text |
id | pubmed-3521349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35213492012-12-14 Effects of body position on the ventilatory response to hypercapnia Donina, Zh A Danilova, GA Aleksandrova, NP Eur J Med Res Research Effect of posture on the hypercapnic ventilatory response was studied on the anaesthetized rats by using rebreathing techniques in the supine and head-down positions. There were no statistically significant alterations in tidal volume, frequency, minute ventilation, and P(ET)CO(2 )between the head-down and supine positions during breathing at rest. However, the esophageal pressure inspiratory swings were significantly greater in the head-down compared with supine position. Moreover, we found that body position did not affect the hypercapnic ventilatory response, but did affect the relationship between inspiratory driving pressure and the increase of end tidal PCO(2). Greater inspiratory pressure is required to maintain the same level of the ventilatory response to hypercapnia in the horizontal position with the head-down. We believe that the discrepancy between postural alterations in the hypercapnic ventilatory and pressure responses is presumably a result of decreased lung compliance and increased airflow impedance of respiratory system in the head-down position. BioMed Central 2009-12-07 /pmc/articles/PMC3521349/ /pubmed/20156728 http://dx.doi.org/10.1186/2047-783X-14-S4-63 Text en Copyright ©2009 I. Holzapfel Publishers |
spellingShingle | Research Donina, Zh A Danilova, GA Aleksandrova, NP Effects of body position on the ventilatory response to hypercapnia |
title | Effects of body position on the ventilatory response to hypercapnia |
title_full | Effects of body position on the ventilatory response to hypercapnia |
title_fullStr | Effects of body position on the ventilatory response to hypercapnia |
title_full_unstemmed | Effects of body position on the ventilatory response to hypercapnia |
title_short | Effects of body position on the ventilatory response to hypercapnia |
title_sort | effects of body position on the ventilatory response to hypercapnia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521349/ https://www.ncbi.nlm.nih.gov/pubmed/20156728 http://dx.doi.org/10.1186/2047-783X-14-S4-63 |
work_keys_str_mv | AT doninazha effectsofbodypositionontheventilatoryresponsetohypercapnia AT danilovaga effectsofbodypositionontheventilatoryresponsetohypercapnia AT aleksandrovanp effectsofbodypositionontheventilatoryresponsetohypercapnia |