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Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy

OBJECTIVE: Diabetic autonomic neuropathy (DAN) is one of the chronic complications of diabetes mellitus which can involve one or more organ systems. DAN without apparent symptoms is more often in childhood and adolescence. While heart rate variability (HRV) and Ewing's battery of cardiovascular...

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Autores principales: Ciljakova, M, Vojtkova, J, Durdik, P, Turcan, T, Petrikova, M, Michnova, Z, Banovcin, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521379/
https://www.ncbi.nlm.nih.gov/pubmed/20156724
http://dx.doi.org/10.1186/2047-783X-14-S4-45
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author Ciljakova, M
Vojtkova, J
Durdik, P
Turcan, T
Petrikova, M
Michnova, Z
Banovcin, P
author_facet Ciljakova, M
Vojtkova, J
Durdik, P
Turcan, T
Petrikova, M
Michnova, Z
Banovcin, P
author_sort Ciljakova, M
collection PubMed
description OBJECTIVE: Diabetic autonomic neuropathy (DAN) is one of the chronic complications of diabetes mellitus which can involve one or more organ systems. DAN without apparent symptoms is more often in childhood and adolescence. While heart rate variability (HRV) and Ewing's battery of cardiovascular tests are regarded as a gold standard for the diagnosis of DAN, the examination of cough reflex sensitivity (CRS) is another possibility. The aim of this study was to compare HRV and CRS in children with diabetes mellitus. MATERIALS AND METHODS: Sixty one patients (37 girls, 24 boys) aged 15-19 suffering from diabetes mellitus type 1 completed the study. Based on HRV, patients were divided into 2 groups - with DAN (n = 25) and without DAN (n = 32), 4 patients were excluded because of ambiguous results. CRS was studied in each patient by inhalation of gradually increasing concentration of capsaicin. RESULTS: Subjects with DAN required a significantly higher concentration of capsaicin needed to evoke 2 coughs (median 625 μmol/l, IQR 68.4-625.0 μmol/l vs. median 29.3 μmol/l, IQR 9.8-156.3 μmol/l, P < 0.001) and 5 coughs (median 2500.0 μmol/l, IQR 1250.0-2500.0 μmol/l vs. median 312.5 μmol/l, IQR 117.2-625.0 μmol/l, P < 0.001) compared with those without DAN. Moreover, a strong negative correlation between HRV and CRS was established. CONCLUSION: Diabetes mellitus lowers the cough response. Cough reflex sensitivity appears to be another sensitive method for the evaluation of DAN in diabetes.
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spelling pubmed-35213792012-12-14 Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy Ciljakova, M Vojtkova, J Durdik, P Turcan, T Petrikova, M Michnova, Z Banovcin, P Eur J Med Res Research OBJECTIVE: Diabetic autonomic neuropathy (DAN) is one of the chronic complications of diabetes mellitus which can involve one or more organ systems. DAN without apparent symptoms is more often in childhood and adolescence. While heart rate variability (HRV) and Ewing's battery of cardiovascular tests are regarded as a gold standard for the diagnosis of DAN, the examination of cough reflex sensitivity (CRS) is another possibility. The aim of this study was to compare HRV and CRS in children with diabetes mellitus. MATERIALS AND METHODS: Sixty one patients (37 girls, 24 boys) aged 15-19 suffering from diabetes mellitus type 1 completed the study. Based on HRV, patients were divided into 2 groups - with DAN (n = 25) and without DAN (n = 32), 4 patients were excluded because of ambiguous results. CRS was studied in each patient by inhalation of gradually increasing concentration of capsaicin. RESULTS: Subjects with DAN required a significantly higher concentration of capsaicin needed to evoke 2 coughs (median 625 μmol/l, IQR 68.4-625.0 μmol/l vs. median 29.3 μmol/l, IQR 9.8-156.3 μmol/l, P < 0.001) and 5 coughs (median 2500.0 μmol/l, IQR 1250.0-2500.0 μmol/l vs. median 312.5 μmol/l, IQR 117.2-625.0 μmol/l, P < 0.001) compared with those without DAN. Moreover, a strong negative correlation between HRV and CRS was established. CONCLUSION: Diabetes mellitus lowers the cough response. Cough reflex sensitivity appears to be another sensitive method for the evaluation of DAN in diabetes. BioMed Central 2009-12-07 /pmc/articles/PMC3521379/ /pubmed/20156724 http://dx.doi.org/10.1186/2047-783X-14-S4-45 Text en Copyright ©2009 I. Holzapfel Publishers
spellingShingle Research
Ciljakova, M
Vojtkova, J
Durdik, P
Turcan, T
Petrikova, M
Michnova, Z
Banovcin, P
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
title Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
title_full Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
title_fullStr Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
title_full_unstemmed Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
title_short Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
title_sort cough reflex sensitivity in adolescents with diabetic autonomic neuropathy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521379/
https://www.ncbi.nlm.nih.gov/pubmed/20156724
http://dx.doi.org/10.1186/2047-783X-14-S4-45
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