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Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian g...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Hematologia e Hemoterapia
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521435/ https://www.ncbi.nlm.nih.gov/pubmed/23284243 http://dx.doi.org/10.5581/1516-8484.20110014 |
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author | Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Leite, Ana Claudia Celestino Bezerra dos Anjos, Ana Claudia Mendonça Pinto, Ana Cristina Silva Matta, Andre Palma da Cunha Silva, Célia Maria Silva, Gisele Sampaio Friedrisch, João Ricardo Braga, Josefina Aparecida Pellegrini Lange, Marcos Christiano Figueiredo, Maria Stella Rugani, Marília Álvares Veloso, Orlando Moura, Patrícia Gomes Cortez, Paulo Ivo Adams, Robert Gualandro, Sandra Fátima Menosi de Castilho, Shirley Lopes Thomé, Ursula Zetola, Viviane Flumignan |
author_facet | Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Leite, Ana Claudia Celestino Bezerra dos Anjos, Ana Claudia Mendonça Pinto, Ana Cristina Silva Matta, Andre Palma da Cunha Silva, Célia Maria Silva, Gisele Sampaio Friedrisch, João Ricardo Braga, Josefina Aparecida Pellegrini Lange, Marcos Christiano Figueiredo, Maria Stella Rugani, Marília Álvares Veloso, Orlando Moura, Patrícia Gomes Cortez, Paulo Ivo Adams, Robert Gualandro, Sandra Fátima Menosi de Castilho, Shirley Lopes Thomé, Ursula Zetola, Viviane Flumignan |
author_sort | Lobo, Clarisse Lopes de Castro |
collection | PubMed |
description | BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients. |
format | Online Article Text |
id | pubmed-3521435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Associação Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-35214352013-01-02 Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Leite, Ana Claudia Celestino Bezerra dos Anjos, Ana Claudia Mendonça Pinto, Ana Cristina Silva Matta, Andre Palma da Cunha Silva, Célia Maria Silva, Gisele Sampaio Friedrisch, João Ricardo Braga, Josefina Aparecida Pellegrini Lange, Marcos Christiano Figueiredo, Maria Stella Rugani, Marília Álvares Veloso, Orlando Moura, Patrícia Gomes Cortez, Paulo Ivo Adams, Robert Gualandro, Sandra Fátima Menosi de Castilho, Shirley Lopes Thomé, Ursula Zetola, Viviane Flumignan Rev Bras Hematol Hemoter Special Article BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients. Associação Brasileira de Hematologia e Hemoterapia 2011 /pmc/articles/PMC3521435/ /pubmed/23284243 http://dx.doi.org/10.5581/1516-8484.20110014 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Article Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Leite, Ana Claudia Celestino Bezerra dos Anjos, Ana Claudia Mendonça Pinto, Ana Cristina Silva Matta, Andre Palma da Cunha Silva, Célia Maria Silva, Gisele Sampaio Friedrisch, João Ricardo Braga, Josefina Aparecida Pellegrini Lange, Marcos Christiano Figueiredo, Maria Stella Rugani, Marília Álvares Veloso, Orlando Moura, Patrícia Gomes Cortez, Paulo Ivo Adams, Robert Gualandro, Sandra Fátima Menosi de Castilho, Shirley Lopes Thomé, Ursula Zetola, Viviane Flumignan Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title | Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_full | Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_fullStr | Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_full_unstemmed | Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_short | Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_sort | brazilian guidelines for transcranial doppler in children and adolescents with sickle cell disease |
topic | Special Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521435/ https://www.ncbi.nlm.nih.gov/pubmed/23284243 http://dx.doi.org/10.5581/1516-8484.20110014 |
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