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Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease

BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian g...

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Autores principales: Lobo, Clarisse Lopes de Castro, Cançado, Rodolfo Delfini, Leite, Ana Claudia Celestino Bezerra, dos Anjos, Ana Claudia Mendonça, Pinto, Ana Cristina Silva, Matta, Andre Palma da Cunha, Silva, Célia Maria, Silva, Gisele Sampaio, Friedrisch, João Ricardo, Braga, Josefina Aparecida Pellegrini, Lange, Marcos Christiano, Figueiredo, Maria Stella, Rugani, Marília Álvares, Veloso, Orlando, Moura, Patrícia Gomes, Cortez, Paulo Ivo, Adams, Robert, Gualandro, Sandra Fátima Menosi, de Castilho, Shirley Lopes, Thomé, Ursula, Zetola, Viviane Flumignan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Hematologia e Hemoterapia 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521435/
https://www.ncbi.nlm.nih.gov/pubmed/23284243
http://dx.doi.org/10.5581/1516-8484.20110014
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author Lobo, Clarisse Lopes de Castro
Cançado, Rodolfo Delfini
Leite, Ana Claudia Celestino Bezerra
dos Anjos, Ana Claudia Mendonça
Pinto, Ana Cristina Silva
Matta, Andre Palma da Cunha
Silva, Célia Maria
Silva, Gisele Sampaio
Friedrisch, João Ricardo
Braga, Josefina Aparecida Pellegrini
Lange, Marcos Christiano
Figueiredo, Maria Stella
Rugani, Marília Álvares
Veloso, Orlando
Moura, Patrícia Gomes
Cortez, Paulo Ivo
Adams, Robert
Gualandro, Sandra Fátima Menosi
de Castilho, Shirley Lopes
Thomé, Ursula
Zetola, Viviane Flumignan
author_facet Lobo, Clarisse Lopes de Castro
Cançado, Rodolfo Delfini
Leite, Ana Claudia Celestino Bezerra
dos Anjos, Ana Claudia Mendonça
Pinto, Ana Cristina Silva
Matta, Andre Palma da Cunha
Silva, Célia Maria
Silva, Gisele Sampaio
Friedrisch, João Ricardo
Braga, Josefina Aparecida Pellegrini
Lange, Marcos Christiano
Figueiredo, Maria Stella
Rugani, Marília Álvares
Veloso, Orlando
Moura, Patrícia Gomes
Cortez, Paulo Ivo
Adams, Robert
Gualandro, Sandra Fátima Menosi
de Castilho, Shirley Lopes
Thomé, Ursula
Zetola, Viviane Flumignan
author_sort Lobo, Clarisse Lopes de Castro
collection PubMed
description BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients.
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spelling pubmed-35214352013-01-02 Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Leite, Ana Claudia Celestino Bezerra dos Anjos, Ana Claudia Mendonça Pinto, Ana Cristina Silva Matta, Andre Palma da Cunha Silva, Célia Maria Silva, Gisele Sampaio Friedrisch, João Ricardo Braga, Josefina Aparecida Pellegrini Lange, Marcos Christiano Figueiredo, Maria Stella Rugani, Marília Álvares Veloso, Orlando Moura, Patrícia Gomes Cortez, Paulo Ivo Adams, Robert Gualandro, Sandra Fátima Menosi de Castilho, Shirley Lopes Thomé, Ursula Zetola, Viviane Flumignan Rev Bras Hematol Hemoter Special Article BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients. Associação Brasileira de Hematologia e Hemoterapia 2011 /pmc/articles/PMC3521435/ /pubmed/23284243 http://dx.doi.org/10.5581/1516-8484.20110014 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Article
Lobo, Clarisse Lopes de Castro
Cançado, Rodolfo Delfini
Leite, Ana Claudia Celestino Bezerra
dos Anjos, Ana Claudia Mendonça
Pinto, Ana Cristina Silva
Matta, Andre Palma da Cunha
Silva, Célia Maria
Silva, Gisele Sampaio
Friedrisch, João Ricardo
Braga, Josefina Aparecida Pellegrini
Lange, Marcos Christiano
Figueiredo, Maria Stella
Rugani, Marília Álvares
Veloso, Orlando
Moura, Patrícia Gomes
Cortez, Paulo Ivo
Adams, Robert
Gualandro, Sandra Fátima Menosi
de Castilho, Shirley Lopes
Thomé, Ursula
Zetola, Viviane Flumignan
Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
title Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
title_full Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
title_fullStr Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
title_full_unstemmed Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
title_short Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
title_sort brazilian guidelines for transcranial doppler in children and adolescents with sickle cell disease
topic Special Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521435/
https://www.ncbi.nlm.nih.gov/pubmed/23284243
http://dx.doi.org/10.5581/1516-8484.20110014
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