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Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models

Rheumatoid arthritis (RA) is a polygenic autoimmune disease primarily affecting the synovial joints. Numerous animal models show similarities to RA in humans; some of them not only mimic the clinical phenotypes but also demonstrate the involvement of homologous genomic regions in RA. This paper comp...

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Autores principales: Besenyei, Timea, Kadar, Andras, Tryniszewska, Beata, Kurko, Julia, Rauch, Tibor A., Glant, Tibor T., Mikecz, Katalin, Szekanecz, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521484/
https://www.ncbi.nlm.nih.gov/pubmed/23251214
http://dx.doi.org/10.1155/2012/284751
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author Besenyei, Timea
Kadar, Andras
Tryniszewska, Beata
Kurko, Julia
Rauch, Tibor A.
Glant, Tibor T.
Mikecz, Katalin
Szekanecz, Zoltan
author_facet Besenyei, Timea
Kadar, Andras
Tryniszewska, Beata
Kurko, Julia
Rauch, Tibor A.
Glant, Tibor T.
Mikecz, Katalin
Szekanecz, Zoltan
author_sort Besenyei, Timea
collection PubMed
description Rheumatoid arthritis (RA) is a polygenic autoimmune disease primarily affecting the synovial joints. Numerous animal models show similarities to RA in humans; some of them not only mimic the clinical phenotypes but also demonstrate the involvement of homologous genomic regions in RA. This paper compares corresponding non-MHC genomic regions identified in rodent and human genome-wide association studies (GWAS). To date, over 30 non-MHC RA-associated loci have been identified in humans, and over 100 arthritis-associated loci have been identified in rodent models of RA. The genomic regions associated with the disease are designated by the name(s) of the gene having the most frequent and consistent RA-associated SNPs or a function suggesting their involvement in inflammatory or autoimmune processes. Animal studies on rats and mice preferentially have used single sequence length polymorphism (SSLP) markers to identify disease-associated qualitative and quantitative trait loci (QTLs) in the genome of F2 hybrids of arthritis-susceptible and arthritis-resistant rodent strains. Mouse GWAS appear to be far ahead of rat studies, and significantly more mouse QTLs correspond to human RA risk alleles.
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spelling pubmed-35214842012-12-18 Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models Besenyei, Timea Kadar, Andras Tryniszewska, Beata Kurko, Julia Rauch, Tibor A. Glant, Tibor T. Mikecz, Katalin Szekanecz, Zoltan Clin Dev Immunol Review Article Rheumatoid arthritis (RA) is a polygenic autoimmune disease primarily affecting the synovial joints. Numerous animal models show similarities to RA in humans; some of them not only mimic the clinical phenotypes but also demonstrate the involvement of homologous genomic regions in RA. This paper compares corresponding non-MHC genomic regions identified in rodent and human genome-wide association studies (GWAS). To date, over 30 non-MHC RA-associated loci have been identified in humans, and over 100 arthritis-associated loci have been identified in rodent models of RA. The genomic regions associated with the disease are designated by the name(s) of the gene having the most frequent and consistent RA-associated SNPs or a function suggesting their involvement in inflammatory or autoimmune processes. Animal studies on rats and mice preferentially have used single sequence length polymorphism (SSLP) markers to identify disease-associated qualitative and quantitative trait loci (QTLs) in the genome of F2 hybrids of arthritis-susceptible and arthritis-resistant rodent strains. Mouse GWAS appear to be far ahead of rat studies, and significantly more mouse QTLs correspond to human RA risk alleles. Hindawi Publishing Corporation 2012 2012-12-06 /pmc/articles/PMC3521484/ /pubmed/23251214 http://dx.doi.org/10.1155/2012/284751 Text en Copyright © 2012 Timea Besenyei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Besenyei, Timea
Kadar, Andras
Tryniszewska, Beata
Kurko, Julia
Rauch, Tibor A.
Glant, Tibor T.
Mikecz, Katalin
Szekanecz, Zoltan
Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
title Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
title_full Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
title_fullStr Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
title_full_unstemmed Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
title_short Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
title_sort non-mhc risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521484/
https://www.ncbi.nlm.nih.gov/pubmed/23251214
http://dx.doi.org/10.1155/2012/284751
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