A UV-independent pathway to melanoma carcinogenesis in the redhair-fairskin background

People with pale skin, red hair, freckles, and an inability to tan—the “redhair/fairskin” phenotype— are at highest risk of developing melanoma, compared to all other pigmentation types(1). Genetically, this phenotype is frequently the product of inactivating polymorphisms in the Melanocortin 1 rece...

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Detalles Bibliográficos
Autores principales: Mitra, Devarati, Luo, Xi, Morgan, Ann, Wang, Jin, Hoang, Mai P., Lo, Jennifer, Guerrero, Candace R., Lennerz, Jochen K., Mihm, Martin C., Wargo, Jennifer A., Robinson, Kathleen C., Devi, Suprabha P., Vanover, Jillian C., D’Orazio, John A., McMahon, Martin, Bosenberg, Marcus W., Haigis, Kevin M., Haber, Daniel A., Wang, Yinsheng, Fisher, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521494/
https://www.ncbi.nlm.nih.gov/pubmed/23123854
http://dx.doi.org/10.1038/nature11624

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