Receptor Tyrosine Kinase ErbB2 Translocates into Mitochondria and Regulates Cellular Metabolism

It is well known that ErbB2, a receptor tyrosine kinase, localizes on the plasma membrane. Here we describe a novel observation that ErbB2 also localizes in mitochondria of cancer cells and patient samples. We found that ErbB2 translocates into mitochondria through the association with mtHSP70. Addi...

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Detalles Bibliográficos
Autores principales: Ding, Yan, Liu, Zixing, Desai, Shruti, Zhao, Yuhua, Liu, Hao, Pannell, Lewis K, Yi, Hong, Wright, Elizabeth R, Owen, Laurie B, Dean-Colomb, Windy, Fodstad, Oystein, Lu, Jianrong, LeDoux, Susan P, Wilson, Glenn L, Tan, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521558/
https://www.ncbi.nlm.nih.gov/pubmed/23232401
http://dx.doi.org/10.1038/ncomms2236

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