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Non-micro-short RNAs: the new kids on the block
The advent of ultra–high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a va...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521675/ https://www.ncbi.nlm.nih.gov/pubmed/23239791 http://dx.doi.org/10.1091/mbc.E12-10-0716 |
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author | Dey, Bijan K. Mueller, Adam C. Dutta, Anindya |
author_facet | Dey, Bijan K. Mueller, Adam C. Dutta, Anindya |
author_sort | Dey, Bijan K. |
collection | PubMed |
description | The advent of ultra–high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16–40 nucleotides in size. We will highlight how some of these non-micro-short RNAs were discovered, as well as their biogenesis, potential mechanisms of action, and role in diverse biological processes, development, and disease. Finally, we will describe what must be done to further our understanding of these enigmatic molecules. |
format | Online Article Text |
id | pubmed-3521675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-35216752013-03-02 Non-micro-short RNAs: the new kids on the block Dey, Bijan K. Mueller, Adam C. Dutta, Anindya Mol Biol Cell Perspective The advent of ultra–high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16–40 nucleotides in size. We will highlight how some of these non-micro-short RNAs were discovered, as well as their biogenesis, potential mechanisms of action, and role in diverse biological processes, development, and disease. Finally, we will describe what must be done to further our understanding of these enigmatic molecules. The American Society for Cell Biology 2012-12-15 /pmc/articles/PMC3521675/ /pubmed/23239791 http://dx.doi.org/10.1091/mbc.E12-10-0716 Text en © 2012 Dey et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Perspective Dey, Bijan K. Mueller, Adam C. Dutta, Anindya Non-micro-short RNAs: the new kids on the block |
title | Non-micro-short RNAs: the new kids on the block |
title_full | Non-micro-short RNAs: the new kids on the block |
title_fullStr | Non-micro-short RNAs: the new kids on the block |
title_full_unstemmed | Non-micro-short RNAs: the new kids on the block |
title_short | Non-micro-short RNAs: the new kids on the block |
title_sort | non-micro-short rnas: the new kids on the block |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521675/ https://www.ncbi.nlm.nih.gov/pubmed/23239791 http://dx.doi.org/10.1091/mbc.E12-10-0716 |
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