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RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection

NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as a...

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Autores principales: Luco, Sophie, Delmas, Olivier, Vidalain, Pierre-Olivier, Tangy, Frédéric, Weil, Robert, Bourhy, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521698/
https://www.ncbi.nlm.nih.gov/pubmed/23271966
http://dx.doi.org/10.1371/journal.ppat.1003060
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author Luco, Sophie
Delmas, Olivier
Vidalain, Pierre-Olivier
Tangy, Frédéric
Weil, Robert
Bourhy, Hervé
author_facet Luco, Sophie
Delmas, Olivier
Vidalain, Pierre-Olivier
Tangy, Frédéric
Weil, Robert
Bourhy, Hervé
author_sort Luco, Sophie
collection PubMed
description NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits all the properties of a NF-κB protein. Although its sequence does not include a transactivation domain, identifying it as a class I member of the NF-κB family, it is able to potentiate RelA-mediated transactivation and stabilize dimers comprising p50. Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection. It is also targeted by the matrix protein of lyssaviruses, the agents of rabies, resulting in an inhibition of the NF-κB pathway. Taken together, our data provide the description of a novel functional member of the NF-κB family, which plays a key role in the induction of anti-viral innate immune response.
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spelling pubmed-35216982012-12-27 RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection Luco, Sophie Delmas, Olivier Vidalain, Pierre-Olivier Tangy, Frédéric Weil, Robert Bourhy, Hervé PLoS Pathog Research Article NF-κB transcription factors are crucial for many cellular processes. NF-κB is activated by viral infections to induce expression of antiviral cytokines. Here, we identified a novel member of the human NF-κB family, denoted RelAp43, the nucleotide sequence of which contains several exons as well as an intron of the RelA gene. RelAp43 is expressed in all cell lines and tissues tested and exhibits all the properties of a NF-κB protein. Although its sequence does not include a transactivation domain, identifying it as a class I member of the NF-κB family, it is able to potentiate RelA-mediated transactivation and stabilize dimers comprising p50. Furthermore, RelAp43 stimulates the expression of HIAP1, IRF1, and IFN-β - three genes involved in cell immunity against viral infection. It is also targeted by the matrix protein of lyssaviruses, the agents of rabies, resulting in an inhibition of the NF-κB pathway. Taken together, our data provide the description of a novel functional member of the NF-κB family, which plays a key role in the induction of anti-viral innate immune response. Public Library of Science 2012-12-13 /pmc/articles/PMC3521698/ /pubmed/23271966 http://dx.doi.org/10.1371/journal.ppat.1003060 Text en © 2012 Luco et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Luco, Sophie
Delmas, Olivier
Vidalain, Pierre-Olivier
Tangy, Frédéric
Weil, Robert
Bourhy, Hervé
RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection
title RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection
title_full RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection
title_fullStr RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection
title_full_unstemmed RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection
title_short RelAp43, a Member of the NF-κB Family Involved in Innate Immune Response against Lyssavirus Infection
title_sort relap43, a member of the nf-κb family involved in innate immune response against lyssavirus infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521698/
https://www.ncbi.nlm.nih.gov/pubmed/23271966
http://dx.doi.org/10.1371/journal.ppat.1003060
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