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Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran

BACKGROUND: Thalassemia is the most common monogenic disease in South-East of Iran. Despite the 70% reduction in Iranian thalassemia cases after thalassemia control comprehensive program, 601 affected babies were born in Sistan and Balouchistan Province, Iran from 2002 to 2010, so this study aims at...

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Autores principales: Miri-Moghaddam, E, Naderi, M, Izadi, S, Mashhadi, MA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521888/
https://www.ncbi.nlm.nih.gov/pubmed/23304678
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author Miri-Moghaddam, E
Naderi, M
Izadi, S
Mashhadi, MA
author_facet Miri-Moghaddam, E
Naderi, M
Izadi, S
Mashhadi, MA
author_sort Miri-Moghaddam, E
collection PubMed
description BACKGROUND: Thalassemia is the most common monogenic disease in South-East of Iran. Despite the 70% reduction in Iranian thalassemia cases after thalassemia control comprehensive program, 601 affected babies were born in Sistan and Balouchistan Province, Iran from 2002 to 2010, so this study aims at investigating the causes of new thalassemia cases. METHODS: Data from this retrospective cross-sectional study was collected through interviews and information in the patients’ hospital records. RESULTS: Data revealed that 52.4% of fathers and 78.4% of mothers of thalassemic children had elementary education or less. In addition, 78.6% of the couples did not undergo premarital screening for thalassemia and 71.2% of the couples were not notified of their own minor thalassemia until a child was born with major thalassemia. Of the diagnosed minor couples, about 25% did PND and the others did not carry out because mothers were unaware of proper gestational age and of the importance of this issue, financial problems, and the husbands’ disagreement to take the tests. Moreover, 16 mothers, in spite of being diagnosed of having a major fetus, refused to terminate the pregnancy. CONCLUSION: The most preventable causes for affected births include couples’ unawareness of being minor and unawares of the PND importance and process.
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spelling pubmed-35218882013-01-09 Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran Miri-Moghaddam, E Naderi, M Izadi, S Mashhadi, MA Iran J Public Health Original Article BACKGROUND: Thalassemia is the most common monogenic disease in South-East of Iran. Despite the 70% reduction in Iranian thalassemia cases after thalassemia control comprehensive program, 601 affected babies were born in Sistan and Balouchistan Province, Iran from 2002 to 2010, so this study aims at investigating the causes of new thalassemia cases. METHODS: Data from this retrospective cross-sectional study was collected through interviews and information in the patients’ hospital records. RESULTS: Data revealed that 52.4% of fathers and 78.4% of mothers of thalassemic children had elementary education or less. In addition, 78.6% of the couples did not undergo premarital screening for thalassemia and 71.2% of the couples were not notified of their own minor thalassemia until a child was born with major thalassemia. Of the diagnosed minor couples, about 25% did PND and the others did not carry out because mothers were unaware of proper gestational age and of the importance of this issue, financial problems, and the husbands’ disagreement to take the tests. Moreover, 16 mothers, in spite of being diagnosed of having a major fetus, refused to terminate the pregnancy. CONCLUSION: The most preventable causes for affected births include couples’ unawareness of being minor and unawares of the PND importance and process. Tehran University of Medical Sciences 2012-11-01 /pmc/articles/PMC3521888/ /pubmed/23304678 Text en Copyright © Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License ((CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Miri-Moghaddam, E
Naderi, M
Izadi, S
Mashhadi, MA
Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran
title Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran
title_full Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran
title_fullStr Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran
title_full_unstemmed Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran
title_short Causes of New Cases of Major Thalassemia in Sistan and Balouchistan Province in South-East of Iran
title_sort causes of new cases of major thalassemia in sistan and balouchistan province in south-east of iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521888/
https://www.ncbi.nlm.nih.gov/pubmed/23304678
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