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Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

BACKGROUND: Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes. In this study, we investigat...

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Detalles Bibliográficos
Autores principales:	Gandhy, Shruti U, Kim, KyoungHyun, Larsen, Lesley, Rosengren, Rhonda J, Safe, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522018/ https://www.ncbi.nlm.nih.gov/pubmed/23194063 http://dx.doi.org/10.1186/1471-2407-12-564

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